Wang XD, Su XQ, Gao H. Association of Sijunzi decoction plus chemotherapy with gastrointestinal function and serum markers in patients after gastric carcinoma surgery. World J Gastrointest Surg 2025; 17(4): 100800 [DOI: 10.4240/wjgs.v17.i4.100800]
Corresponding Author of This Article
Hong Gao, PhD, Department of Oncology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Huanggu District, Shenyang 110032, Liaoning Province, China. lnzy_gaohong@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Apr 27, 2025; 17(4): 100800 Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.100800
Association of Sijunzi decoction plus chemotherapy with gastrointestinal function and serum markers in patients after gastric carcinoma surgery
Xiao-Dong Wang, Xiao-Qing Su, Hong Gao
Xiao-Dong Wang, Hong Gao, Department of Oncology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, Liaoning Province, China
Xiao-Qing Su, Department of Traditional Chinese Medicine, Tawan Community Health Service Center, Shenyang 110032, Liaoning Province, China
Co-first authors: Xiao-Dong Wang and Xiao-Qing Su.
Author contributions: Wang XD and Su XQ designed the study, collected and analyzed data, and wrote the manuscript; Wang XD and Su XQ participated in the study’s conception and data collection; Wang XD, Su XQ and Gao H participated in study design and provided guidance. All authors read and approved the final version. Wang XD and Su XQ contributed equally to this work as co-first authors.
Supported by Liaoning Provincial Science and Technology Plan Joint Plan, No. 2023JH2/101700149.
Institutional review board statement: This study was approved by the Ethic Committee of Affiliated Hospital of Liaoning University of Traditional Chinese Medicine.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong Gao, PhD, Department of Oncology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Huanggu District, Shenyang 110032, Liaoning Province, China. lnzy_gaohong@163.com
Received: December 20, 2024 Revised: January 24, 2025 Accepted: February 25, 2025 Published online: April 27, 2025 Processing time: 98 Days and 23.5 Hours
Core Tip
Core Tip: Considering the scarcity of existing research regarding the association of the combination of Sijunzi decoction and chemotherapy with the gastrointestinal function and serum markers of patients after gastric cancer (GC) surgery, this investigation has meticulously conducted a comprehensive, multi-faceted comparative analysis of the clinical efficacy between the therapeutic approach of Sijunzi decoction combined with chemotherapy and chemotherapy alone in such patient populations. The assessment covers a wide array of aspects, including gastrointestinal function, serum markers, nutritional parameters, traditional Chinese medicine syndrome scores, and adverse events. The research results confirmed that the combined Sijunzi decoction and chemotherapy treatment effectively alleviated symptoms, such as poor appetite, epigastric distension and pain, fatigue and weakness, and abdominal distension after eating, besides its remarkable capacity to improve gastrointestinal function, optimize nutritional status, and rectify abnormally increased serum tumor markers in patients after GC surgery. These results will provide novel perspectives and valuable guidance for the clinical management of patients after GC surgery.
