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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Mar 27, 2025; 17(3): 99425
Published online Mar 27, 2025. doi: 10.4240/wjgs.v17.i3.99425
Published online Mar 27, 2025. doi: 10.4240/wjgs.v17.i3.99425
Optimal timing of endoscopic biliary drainage for bile duct leaks: A multicenter, retrospective, clinical study
De-Xin Chen, Kai-Xuan Fang, Sheng-Xin Chen, Ya-Qi Zhai, Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China
De-Xin Chen, Kai-Xuan Fang, Graduate School, Chinese PLA General Hospital, Beijing 100853, China
Kai-Xuan Fang, Department of Gastroenterology and Hepatology, The 960th Hospital of PLA, Jinan 050035, Shandong Province, China
Sen-Lin Hou, Department of Gastroenterology and Hepatology, The Second Hospital of Hebei Medical University, Hebei 050035, China
Gui-Hai Wen, Department of Gastroenterology and Hepatology, Handan Central Hospital, Hebei 056001, China
Hai-Kun Yang, Department of Gastroenterology and Hepatology, Shanxi Provincial People’s Hospital, Shanxi 030012, China
Da-Peng Shi, Department of Gastroenterology and Hepatology, First Affiliated Hospital of Army Medical University of PLA, Chongqing 400042, China
Qing-Xin Lu, Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Army Medical University of PLA, Chongqing 400042, China
Ming-Yang Li, Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China
Co-first authors: De-Xin Chen and Kai-Xuan Fang.
Co-corresponding authors: Ya-Qi Zhai and Ming-Yang Li.
Author contributions: Chen DX and Fang KX contributed to analysis, interpretation of data, drafting the article, they contributed equally to this article, they are the co-first authors of this manuscript; Chen SX, Hou SL, Wen GH, Yang HK, Shi DP, and Lu QX contributed to acquisition of data; Li MY is designated as the primary contact for all correspondence with the journal; Zhai YQ and Li MY contributed to revising, editing and drafting article, they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors have read and approved the final manuscript.
Supported by the National Key Research and Development Program, China, No. 2022YFC2503603.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the General Hospital of the People’s Liberation Army, approval No. S2023-067-01.
Informed consent statement: The informed consent was waived by the Institutional Review Board.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data sets used and analyzed during the current study are available from the corresponding author at mingyangli_pla@163.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Yang Li, MD, PhD, Chief Physician, Department of Gastro
Received: July 22, 2024
Revised: January 14, 2025
Accepted: February 5, 2025
Published online: March 27, 2025
Processing time: 216 Days and 16.7 Hours
Revised: January 14, 2025
Accepted: February 5, 2025
Published online: March 27, 2025
Processing time: 216 Days and 16.7 Hours
Core Tip
Core Tip: In this multicenter study, 94 patients with bile duct leaks who underwent endoscopic retrograde cholangiopancreatography (ERCP) were retrospectively analyzed. We found that performing ERCP within 3 weeks was associated with higher success rates and a lower incidence of biliary stricture than later interventions. Multivariate analysis confirmed that early ERCP was a key factor for improved outcomes. If patients with bile duct leaks do not respond to conservative treatment, ERCP is suggested to be performed within 3 weeks.