Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Feb 27, 2025; 17(2): 99531
Published online Feb 27, 2025. doi: 10.4240/wjgs.v17.i2.99531
Prognostic value of combined detection of alpha-fetoprotein, plasma prothrombin activity, and serum prealbumin in acute-on-chronic liver failure
Rui-Xian Duan, Ling Liu, Yan Wang, Wen-Ming Wu
Rui-Xian Duan, Yan Wang, Department of Infectious Diseases, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan 030032, Shanxi Province, China
Ling Liu, Department of Pulmonary Diseases, Shanxi Provincial Integrated TCM and WM Hospital, Taiyuan 030013, Shanxi Province, China
Wen-Ming Wu, Clinical Laboratory, Shanxi Provincial People’s Hospital, Taiyuan 030023, Shanxi Province, China
Author contributions: Duan RX performed the study, designed the research and wrote the manuscript; Duan RX, Liu L, Wang Y, and Wu WM analyzed the data; and all authors have read and approve the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Shanxi Bethune Hospital.
Informed consent statement: The requirement for written informed consent was waived due to retrospective design of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Dataset available from the corresponding author at wu.wenming1007@163.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Ming Wu, Associate Chief Physician, Clinical Laboratory, Shanxi Provincial People’s Hospital, No. 359 Heping North Road, Jiancaoping District, Taiyuan 030023, Shanxi Province, China. wu.wenming1007@163.com
Received: October 11, 2024
Revised: November 11, 2024
Accepted: December 19, 2024
Published online: February 27, 2025
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Core Tip

Core Tip: Acute-on-chronic liver failure (ACLF) is a type of chronic hepatopathy-based liver disease featuring severe acute liver function. They are significantly influenced by clinical treatment regimens and disease conditions, with relatively low overall sensitivity and accuracy, despite the presence of multiple prognostic assessment indicators for ACLF. This study aims to investigate the prognostic value of the combined detection of alpha-fetoprotein, plasma prothrombin activity, and serum prealbumin in ACLF.