Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2025; 17(1): 96512
Published online Jan 27, 2025. doi: 10.4240/wjgs.v17.i1.96512
Preoperative serum total bilirubin-albumin ratio as a prognostic indicator in patients with hepatitis-related cirrhosis after splenectomy
Yi-Fan Chen, Yu-Xin Lin, Miao-Miao Chi, Da-Qing Li, Lin-Tao Chen, Yu Zhang, Rong-Qian Wu, Zhao-Qing Du
Yi-Fan Chen, Yu-Xin Lin, Miao-Miao Chi, Da-Qing Li, Lin-Tao Chen, Yu Zhang, Zhao-Qing Du, Department of Hepatobiliary Surgery, Shaanxi Provincial People’s Hospital, Xi’an 710068, Shaanxi Province, China
Yi-Fan Chen, Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China
Yu-Xin Lin, Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Miao-Miao Chi, Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China
Rong-Qian Wu, National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Zhao-Qing Du, National Engineering Research Center for Miniaturized Detection Systems, College of Life Sciences, Northwest University of Xi’an, Xi’an 710069, Shaanxi Province, China
Author contributions: Du ZQ conceived and designed the overall research framework; Chen YF, Lin YX, Chi MM, Li DQ, and Chen LT did the data analysis; Lin YX, Chi MM, and Zhang Y provided the resources and supervision; Chen YF, Wu RQ, and Du ZQ wrote the draft; all authors contributed to the study, and read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Shaanxi Provincial People’s Hospital (Approval Number: SPPH-LLBG-17-3.2).
Informed consent statement: Written informed consent from the patients was waived due to the retrospective nature of this study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhao-Qing Du, PhD, Academic Editor, Researcher, Department of Hepatobiliary Surgery, Shaanxi Provincial People’s Hospital, No. 256 Youyi West Road, Xi’an 710068, Shaanxi Province, China. duzhaoqing2007@126.com
Received: May 8, 2024
Revised: September 6, 2024
Accepted: October 28, 2024
Published online: January 27, 2025
Processing time: 232 Days and 23.4 Hours
Core Tip

Core Tip: High serum total bilirubin-albumin (B/A) ratio shows distinct specificities in hepatitis-related cirrhosis patients. In this study, we investigated the B/A ratio as a predictor of overall survival (OS) of hepatitis-related cirrhosis patients after splenectomy. Based on the cutoff point, patients with a high B/A ratio showed a worse long-term survival in the overall cohort and in the subgroups of patients with hepatpcellular carcinoma (HCC), without HCC, early Child-Pugh stage, low albumin-bilirubin grade, and model for end-stage liver disease score ≥ 10. B/A ratio was the only independent risk factor for OS. Because its convenience and effectiveness, the B/A ratio may be used to predict the prognosis of such patients.