Microbiota in patients with cefuroxime resistance and anal fistula revealed by 16S ribosomal DNA

doi:10.4240/wjgs.v17.i1.100790

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Jan 27, 2025; 17(1): 100790
Published online Jan 27, 2025. doi: 10.4240/wjgs.v17.i1.100790

Microbiota in patients with cefuroxime resistance and anal fistula revealed by 16S ribosomal DNA

Yi-Ting Ling, Fei Yao, Sen-Juan Li, Chen-Xi Cao, Zhen-Wei Chen, Min Qiu, Bu-Zhuo Li, Bi-Wen Hu, Shen-Yan Zhong, Guang-Lei Hu, Jia-Hua Li

Yi-Ting Ling, Fei Yao, Sen-Juan Li, Chen-Xi Cao, Zhen-Wei Chen, Min Qiu, Bu-Zhuo Li, Bi-Wen Hu, Shen-Yan Zhong, Guang-Lei Hu, Jia-Hua Li, Department of Anorectal Surgery, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China

Author contributions: Ling YT and Yao F designed the research study; Ling YT, Li SJ, Cao CX, and Chen ZW performed the research; Qiu M, Hu GL, and Li JH contributed new reagents and analytic tools; Ling YT, Li BZ, Hu BW, and Yao F analyzed the data and wrote the manuscript; Zhong SY debugged the code and organized the visualization results; and all authors have read and approved the final manuscript.

Supported by the Jiaxing Science and Technology Project, No. 2023AD11016 and No. 2023AD31028.

Institutional review board statement: This study was reviewed and approved by the Medical Ethics Committee of the Second Affiliated Hospital of Jiaxing University, approval Jiaxing Second Hospital Ethics Review, No. 2023-028.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: No additional data are available.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Fei Yao, MD, Department of Anorectal Surgery, The Second Affiliated Hospital of Jiaxing University, No. 397 North Huancheng Road, Nanhu District, Jiaxing 314000, Zhejiang Province, China. yaof890726@163.com

Received: September 6, 2024
Revised: October 11, 2024
Accepted: November 18, 2024
Published online: January 27, 2025
Processing time: 112 Days and 5.9 Hours

Core Tip

Core Tip: This study explores the role of gut microbiota in cefuroxime resistance among anal fistula patients, highlighting the protective effects of butyrate-producing bacteria such as Butyricicoccus and Roseburia. The findings demonstrate that modulating gut microbiota through probiotic intervention can significantly reduce cefuroxime resistance, improve stool consistency, and lower bowel movement frequency. This research offers valuable insights into the potential of microbiota-based strategies to manage antibiotic resistance and enhance perioperative care in anal fistula patients.