Basic Study
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World J Gastrointest Surg. Aug 27, 2024; 16(8): 2679-2688
Published online Aug 27, 2024. doi: 10.4240/wjgs.v16.i8.2679
Effect of growth hormone on colonic anastomosis after intraperitoneal administration of 5-fluorouracil, bleomycin and cisplatin: An experimental study
Ioannis Lambrou, Ioannis Mantzoros, Orestis Ioannidis, Dimitrios Tatsis, Elissavet Anestiadou, Vasiliki Bisbinas, Manousos-Georgios Pramateftakis, Efstathios Kotidis, Barbara Driagka, Ourania Kerasidou, Savvas Symeonidis, Stefanos Bitsianis, Freideriki Sifaki, Konstantinos Angelopoulos, Haralabos Demetriades, Stamatios Angelopoulos
Ioannis Lambrou, Ioannis Mantzoros, Orestis Ioannidis, Dimitrios Tatsis, Elissavet Anestiadou, Manousos-Georgios Pramateftakis, Efstathios Kotidis, Barbara Driagka, Ourania Kerasidou, Savvas Symeonidis, Stefanos Bitsianis, Freideriki Sifaki, Konstantinos Angelopoulos, Haralabos Demetriades, Stamatios Angelopoulos, Fourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki 57010, Greece
Vasiliki Bisbinas, Department of ENT, Royal Cornwall Hospitals NHS Trust, Cornwall TR1 3LJ, United Kingdom
Author contributions: Lambrou I, Ioannidis O, Mantzoros I contributed equally to this work; Lambrou I, Mantzoros I, Pramateftakis MG, Anestiadou E, Driagka B designed and coordinated the research, participated equally in treatment of the animals, performed the experiments and acquired the data; Ioannidis O, Tatsis D, Kotidis E, Kerasidou O, Symeonidis S, Bitsianis S, Sifaki F, Demetriades H, Angelopoulos K, Angelopoulos S analyzed and interpreted the data; Lambrou I, Ioannidis O, Mantzoros I, Tatsis D, Anestiadou E, Bisbinas V wrote the paper; Lambrou I, Ioannidis O, Mantzoros I, Tatsis D, Anestiadou E, Bisbinas V, Driagka B, Pramateftakis MG, Kotidis E, Kerasidou O, Demetriades H, Symeonidis S, Bitsianis S, Sifaki F, Angelopoulos K, Angelopoulos S significantly contributed to the linguistic formatting and correction of the manuscript, revised it critically for important intellectual content, and were responsible for final proof reading of the article.
Institutional review board statement: The study was reviewed and approved by the Faculty of Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Institutional animal care and use committee statement: The research protocol was reviewed and approved by the Institutional Animal Care and Use Committee of the Veterinary Manager of the Prefecture of Thessaloniki according to the Greek Law on the protection of animals and to law 86/609 EEC of the European Union.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: All data are available upon request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Orestis Ioannidis, MD, MSc, PhD, Assistant Professor, Fourth Department of Surgery, Medical School, Aristotle University of Thessaloniki, Stilponos Kyriakides 1 Str, Thessaloniki 57010, Greece. telonakos@hotmail.com
Received: March 6, 2024
Revised: May 20, 2024
Accepted: June 17, 2024
Published online: August 27, 2024
Processing time: 163 Days and 6 Hours
Core Tip

Core Tip: The present study was designed to investigate the effect of growth hormone (GH) on the healing of colonic anastomoses in rats after intraperitoneal administration of 5-fluorouracil, bleomycin and cisplatin. The application of GH was found to have a protective role in the healing of colonic anastomoses in rats by effectively reversing the detrimental effects of chemotherapy.