Case Control Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Aug 27, 2024; 16(8): 2436-2450
Published online Aug 27, 2024. doi: 10.4240/wjgs.v16.i8.2436
Alteration of ascending colon mucosal microbiota in patients after cholecystectomy
Miao-Yan Fan, Qiao-Li Jiang, Meng-Yan Cui, Meng-Qi Zhao, Jing-Jing Wang, Ying-Ying Lu
Miao-Yan Fan, Qiao-Li Jiang, Ying-Ying Lu, Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201803, China
Miao-Yan Fan, Meng-Yan Cui, Meng-Qi Zhao, Jing-Jing Wang, Shanghai Key Laboratory of Pancreatic Diseases, Institute of Translational Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China
Meng-Yan Cui, Meng-Qi Zhao, Ying-Ying Lu, Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201620, China
Co-first authors: Miao-Yan Fan and Qiao-Li Jiang.
Author contributions: Fan MY and Jiang QL drafted the manuscript and collected patient samples and data; Cui MY and Zhao MQ performed the 16S rRNA sequencing data analysis; Wang JJ provided guidance for sample processing methodology; Lu YY was involved in the study design and critical revision of the manuscript; and all authors have read and approved the final manuscript.
Supported by the Shanghai Natural Science Foundation Project, No. 22ZR1453500; and Jiading District Health Commission Scientific Project, No. 2023-KY-01.
Institutional review board statement: This study was reviewed and approved by Shanghai General Hospital’s Ethical Committee [approval No. (2023)252].
Informed consent statement: The written informed consent was obtained from all the patients before sample collection.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Ying Lu, PhD, Associate Chief Physician, Department of Gastroenterology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 800 Huangjiahuayuan Road, Shanghai 201803, China. yingying.lu1@shgh.cn
Received: April 5, 2024
Revised: May 23, 2024
Accepted: July 3, 2024
Published online: August 27, 2024
Processing time: 133 Days and 9.1 Hours
Core Tip

Core Tip: Cholecystectomy is an effective treatment for gallstones, which may change the gut microbiota and relate to colorectal cancer (CRC). To investigate the potential correlation between gut microbiota and cholecystectomy, we performed 16S rRNA sequencing in ascending colon mucosa in post-cholecystectomy patients and healthy controls. We found some altered species that may affect the bile acid metabolism and have a relationship with CRC. Therefore, intestinal flora altered after cholecystectomy, which may be a new target to attenuate related diseases after cholecystectomy.