Wang Y, Li D, Xun J, Wu Y, Wang HL. Construction of prognostic markers for gastric cancer and comprehensive analysis of pyroptosis-related long non-coding RNAs. World J Gastrointest Surg 2024; 16(7): 2281-2295 [PMID: 39087128 DOI: 10.4240/wjgs.v16.i7.2281]
Corresponding Author of This Article
Hong-Lei Wang, Doctor, Chief Physician, Department of Gastrointestinal Surgery, Hospital of Integrated Chinese and Western Medicine, Tianjin University, No. 6 Changjiang Road, Nankai District, Tianjin 300100, China. hongleiwang0319@outlook.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Clinical and Translational Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jul 27, 2024; 16(7): 2281-2295 Published online Jul 27, 2024. doi: 10.4240/wjgs.v16.i7.2281
Construction of prognostic markers for gastric cancer and comprehensive analysis of pyroptosis-related long non-coding RNAs
Yu Wang, Di Li, Jing Xun, Yu Wu, Hong-Lei Wang
Yu Wang, Di Li, Jing Xun, Yu Wu, Hong-Lei Wang, Department of Gastrointestinal Surgery, Hospital of Integrated Chinese and Western Medicine, Tianjin University, Tianjin 300100, China
Author contributions: Wang Y and Li D designed the research; Xun J and Wu Y contributed new reagents/analytic tools; Wang HL analyzed the data; Wang Y wrote the paper; All authors were involved in the critical review of the results and have contributed to read and approved the final manuscript.
Supported byThe Scientific Research Project of Integrated Traditional Chinese and Western Medicine of Tianjin Health Commission Administration of Traditional Chinese Medicine, No. 2021010 and No. 2023166; and Xiao-Ping Chen Foundation for the Development of Science and Technology of Hubei Province, No. CXPJJH122002-073.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Lei Wang, Doctor, Chief Physician, Department of Gastrointestinal Surgery, Hospital of Integrated Chinese and Western Medicine, Tianjin University, No. 6 Changjiang Road, Nankai District, Tianjin 300100, China. hongleiwang0319@outlook.com
Received: April 10, 2024 Revised: May 22, 2024 Accepted: June 14, 2024 Published online: July 27, 2024 Processing time: 102 Days and 23.9 Hours
Core Tip
Core Tip: In this study, China's most common malignancy is gastric cancer (GC), which has a poor survival rate. Pyroptosis is connected to cancer development. The function of pyroptosis-related long non-coding RNAs (PRLs) in GC is uncertain. In our study, we took advantage of the 352 gastric adenocarcinoma samples included in the TCGA database and obtained data on 28 cases related to the pyroptotic genes from the Reactome database. We used the Pearson correlation coefficient method to screen out the long non-coding RNAs associated with pyroptosis. Using univariate Cox analysis, we identified the PRL associated with prognosis. By using PRLs, we created a completely new prognostic marker, which may provide ideas for immunotherapy in GC patients.
