Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jul 27, 2024; 16(7): 2073-2079
Published online Jul 27, 2024. doi: 10.4240/wjgs.v16.i7.2073
The combined detection of carcinoembryonic antigen, carcinogenic antigen 125, and carcinogenic antigen 19-9 in colorectal cancer patients
Ling-Zhen Gong, Qian-Wen Wang, Jie-Wen Zhu
Ling-Zhen Gong, Qian-Wen Wang, Jie-Wen Zhu, Department of Clinical Laboratory, Huangshi Central Hospital (Affiliated Hospital of Hubei Polytechnic University), Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi Tumor Molecular Diagnosis and Treatment Key Laboratory, Huangshi 435000, Hubei Province, China
Author contributions: Gong LZ, Wang QW, Zhu JW contributed equally to this work; Gong LZ, Wang QW designed the research study, performed the primary literature and data extraction, analyzed the data and wrote the manuscript; Gong LZ, Wang QW, Zhu JW were responsible for revising the manuscript for important intellectual content. All authors read and approved the final version.
Institutional review board statement: The study was reviewed and approved by Huangshi Central Hospital.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at 13647146857@163.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie-Wen Zhu, BMed, Associate Chief Technician, Department of Clinical Laboratory, Huangshi Central Hospital (Affiliated Hospital of Hubei Polytechnic University), Hubei Key Laboratory of Kidney Disease Pathogenesis and Intervention, Huangshi Tumor Molecular Diagnosis and Treatment Key Laboratory, Feiyun Street, Xisaishan District, Huangshi 435000, Hubei Province, China. 13647146857@163.com
Received: March 1, 2024
Revised: April 30, 2024
Accepted: May 22, 2024
Published online: July 27, 2024
Processing time: 143 Days and 4.6 Hours
Core Tip

Core Tip: In this study, combined detection of serum carcinoembryonic antigen, cancer antigen (CA) 125 and CA19-9 levels can improve the diagnostic accuracy and predictive value of patients with liver metastases after radical colorectal cancer (CRC) surgery. In particular, CA125 is significant in predicting liver metastasis. Receiver operating characteristic curve analysis showed that the combined detection of these markers has high diagnostic accuracy. Therefore, joint detection of these tumor markers can help early detection and intervention of CRC liver metastasis and improve patient prognosis.