Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2024; 16(6): 1825-1834
Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1825
Peritoneal fluid indocyanine green test for diagnosis of gut leakage in anastomotic leakage rats and colorectal surgery patients
Yu Huang, Tian-Yang Li, Jie-Feng Weng, Hui Liu, Yu-Jie Xu, Shuai Zhang, Wei-Li Gu
Yu Huang, Tian-Yang Li, Jie-Feng Weng, Hui Liu, Yu-Jie Xu, Shuai Zhang, Wei-Li Gu, Department of Surgery, Guangzhou First People's Hospital, Guangzhou 510180, Guangdong Province, China
Author contributions: Huang Y and Gu WL conceived and designed the study; Huang Y and Li TY performed the animal research and collected the data; Huang Y and Weng JF performed the human research and collected the data and wrote the manuscript; Huang Y, Li TY and Zhang S analyzed and interpreted the data; Xu YJ and Liu H revised the manuscript; all authors have read and approved the final manuscript.
Supported by the Science and Technology Projects in Guangzhou, No. 202201010623 and No. 2024A03J1016; Guangzhou Science and Technology Project of Traditional Chinese Medicine and Combined Chinese and Western Medicine, No. 20242A011001; and Guangdong Medical Science and Research Foundation, No. A2024088.
Institutional review board statement: The study was reviewed and approved by the Guangzhou First People’s Hospital Institutional Review Board (Approval No. K-2019-173-01).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Second Affiliated Hospital of South China University of Technology (Protocol No. 2022079).
Conflict-of-interest statement: The authors do not have any conflict of interest to declare.
Data sharing statement: The authors declare that the data supporting the findings of this study are available within the article or from the corresponding authors upon request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu Huang, MD, PhD, Doctor, Department of Surgery, Guangzhou First People's Hospital, No. 1 Panfu Road, Yuexiu District, Guangzhou 510180, Guangdong Province, China. eyhy@scut.edu.cn
Received: January 13, 2024
Revised: April 22, 2024
Accepted: May 6, 2024
Published online: June 27, 2024
Processing time: 168 Days and 10.5 Hours
Core Tip

Core Tip: This study demonstrates the effectiveness of the peritoneal fluid indocyanine green (ICG) test in detecting postoperative gut leakage (GL) using rat models of surgical GL. The ICG test is a highly useful tool for diagnosing GL in patients with colorectal surgery. Our proposed method is a simple technique that can be used for both diagnosing and ruling out GL.