Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2024; 16(6): 1775-1790
Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1775
Metabolic disorders and hepatitis: Insights from a Mendelian randomization study
Ling-Bo Liang, Xiang-Ping Liu, Ting-Rui Mao, Qiao-Li Su
Ling-Bo Liang, Ting-Rui Mao, Qiao-Li Su, General Practice Ward, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Xiang-Ping Liu, Department of Primary Health Care, The Fourth People’s Hospital of Dazhu County, Dazhou 635100, Sichuan Province, China
Author contributions: Su QL and Liang LB and Mao TR designed and performed the experiments; Liang LB and Liu XP provided support for data analysis and writing the manuscript; Su QL provided the supervision, resources, discussion, design and peer review process; all the authors have seen and approved the manuscript.
Conflict-of-interest statement: Prof. Su has nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qiao-Li Su, MM, Professor, General Practice Ward, General Practice Medical Center, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Wuhou District, Chengdu, Chengdu 610041, Sichuan Province, China. 18980601358@163.com
Received: March 12, 2024
Revised: April 30, 2024
Accepted: May 17, 2024
Published online: June 27, 2024
Processing time: 110 Days and 2.4 Hours
Core Tip

Core Tip: In our study, the randomization model was well defined for the exposures [type 2 diabetes mellitus (T2D), hyperlipidemia, and hypertension] and outcomes (chronic hepatitis B and chronic hepatitis C) by two-sample Mendelian randomization (MR) analysis, and they showed capabilities for interaction with chronic hepatitis infection. The results of our MR support a possible causal relationship between different exposures (T2D, hyperlipidemia, and hypertension) and chronic hepatitis progression.