Effect of high-protein peptide-based formula compared with isocaloric isonitrogenous polymeric formula in critically ill surgical patient

doi:10.4240/wjgs.v16.i6.1765

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Clinical Trial

World J Gastrointest Surg. Jun 27, 2024; 16(6): 1765-1774
Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1765

Effect of high-protein peptide-based formula compared with isocaloric isonitrogenous polymeric formula in critically ill surgical patient

Preeda Sumritpradit, Prapimporn Chattranukulchai Shantavasinkul, Winai Ungpinitpong, Pinit Noorit, Chotip Gajaseni

Preeda Sumritpradit, Division of Trauma Surgery and Surgical Critical Care, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

Prapimporn Chattranukulchai Shantavasinkul, Division of Nutrition and Biochemical Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

Prapimporn Chattranukulchai Shantavasinkul, Graduate Program in Nutrition, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

Winai Ungpinitpong, Department of Surgery, Surin Hospital, Surin 32000, Thailand

Pinit Noorit, Department of Surgery, Chonburi Hospital, Chonburi 20000, Thailand

Chotip Gajaseni, Department of Nursing, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand

Author contributions: Sumritpradit P conceived the original idea, designed the study, enrolled subjects, patient care, performed the interpretation of data, wrote manuscript, and revised the manuscript and corresponding to submit for publication; Shantavasinkul PC performed biochemistry analysis, took responsibility for integrity of data, wrote manuscript and revised the manuscript; Ungpinitpong W enrolled subjects, patient care, performed the statistical analysis data, took responsibility for accuracy of data, reviewed the manuscript and provided critical comments; Noorit P enrolled subjects, patient care, performed the interpretation of data, took responsibility for integrity of data, reviewed the manuscript and provided critical comments; Gajaseni C collected the data, coordinate with participants and site staff team for intervention. All authors read and approved the final manuscript.

Institutional review board statement: The study was approved by the Institutional Review Board from all institutes.

Clinical trial registration statement: The study was registered at the Thai Clinical Trials Registry (TCTR20220507003) before the first patient’s enrollment.

Informed consent statement: All patients voluntarily signed and dated the written informed consent.

Conflict-of-interest statement: All authors declare no potential conflicting interests related to this paper.

Data sharing statement: No additional data are available.

CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Preeda Sumritpradit, MD, Associate Professor, Division of Trauma Surgery and Surgical Critical Care, Department of Surgery, Faculty of Medicine Ramathibodi Hospital, Mahidol University, No. 270 Rama VI Road, Thung Phaya Thai, Ratchathewi, Bangkok 10400, Thailand. psumritpradit@gmail.com

Received: January 26, 2024
Revised: April 3, 2024
Accepted: April 22, 2024
Published online: June 27, 2024
Processing time: 155 Days and 20.2 Hours

Core Tip

Core Tip: This study is to focus on early nutrition support by novel high protein, peptide-based formula in various surgical intensive care patients. The formula could help maintaining body weight and muscle mass of patients and help them to meet calories and protein requirement. In addition, this nutrition support improved serum albumin, prealbumin and retinol binding protein which lead to decrease risk of malnutrition. Besides nutritional status outcomes evaluation, we investigate wound healing improvement by plasma fibronectin which is protein for cell adhesion, wound healing and blood clotting in this study. This finding would be helpful for recovery surgical patients after operation.