Clinical Trials Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2024; 16(6): 1742-1748
Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1742
Clinical effect of spleen aminopeptide on improving liver function damage and immune function in children with infant hepatitis syndrome
Xiao-Qing Fang, Tian Gan, Lie-Min Wang
Xiao-Qing Fang, Department of Pediatrics, General Hospital of Central Theater Command of PLA, Wuhan 430061, Hubei Province, China
Tian Gan, Department of Pharmacy, The First People’s Hospital of Jiangxia District, Wuhan 430200, Hubei Province, China
Lie-Min Wang, Department of Neonatal, Central Hospital of Enshi, Enshi 445000, Hubei Province, China
Co-first authors: Xiao-Qing Fang and Tian Gan.
Author contributions: Fang XQ and Gan T designed the research; Fang XQ, Gan T and Wang LM contributed new reagents/analytic tools; Fang XQ, Gan T and Wang LM analyzed the data; Fang XQ and Gan T wrote the paper; All authors were involved in the critical review of the results and have contributed to, read, and approved the final manuscript.
Institutional review board statement: This study protocol was approved by The First People's Hospital of Jiangxia District.
Informed consent statement: All the families have voluntarily participated in the study and have signed informed consent forms. We explained the purpose, process, risks and benefits of the study to all individuals involved in the study orally or in writing, and obtained their informed consent. Participants have the right to know that their participation is voluntary and can withdraw from the study at any time.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data generated from this investigation are available upon reasonable quest from the corresponding author.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lie-Min Wang, Bachelor, Nurse-in-Charge, Department of Neonatal, Central Hospital of Enshi, No. 88 Jinlong Avenue, Enshi 445000, Hubei Province, China. lieminwang@163.com
Received: April 3, 2024
Revised: May 13, 2024
Accepted: May 24, 2024
Published online: June 27, 2024
Processing time: 87 Days and 13.5 Hours
Core Tip

Core Tip: In this study, infant hepatitis syndrome (IHS) is a clinical syndrome in infants less than one year of age with generalized skin jaundice, abnormal liver function, and hepatomegaly due to various etiologies such as infection. The comparative study of IHS was better treated with splenamine combined with reduced glutathione, which effectively improved patients' liver function and immune level, reduced adverse reactions, and provided some reference value for clinical treatment of IHS.