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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2024; 16(6): 1691-1699
Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1691
Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1691
How to apply ex-vivo split liver transplantation safely and feasibly: A three-step approach
Dong Zhao, Tai-Shi Fang, Kang-Jun Zhang, Jian-Xin Tang, Xu Yan, Xin Jin, Lin-Jie Xie, Department of Liver Surgery and Organ Transplantation Center, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China
Qiu-Hua Xie, Wen-Gui Xie, Department of Organ Procurement Organizations, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China
Author contributions: Zhao D contributed to study conception, design, and administrative support; Xie QH, Fang TS, Zhang KJ, Xie WG, and Tang JX contributed to provision of the study materials or patients; Jin X and Xie LJ contributed to collection and assembly of the data; Zhao D and Tang JX contributed to data analysis and interpretation; all authors contributed to manuscript writing and final approval of the manuscript.
Supported by the Shenzhen Science and Technology Research and Development Fund , No. JCYJ20220530163011026 .
Institutional review board statement: The study was reviewed and approved by the ethics committee of Shenzhen Third People’s Hospital (Approval No. 2022-133).
Informed consent statement: All the patients provided informed consent before operation.
Conflict-of-interest statement: The authors have no conflicts of interests or disclosures to report.
Data sharing statement: If anyone needs relevant data, they can contact the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong Zhao, MD, Chief Doctor, Department of Liver Surgery and Organ Transplantation Center, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, No. 29 Bulan Road, Longgang District, Shenzhen 518112, Guangdong Province, China. zdong1233@126.com
Received: February 26, 2024
Revised: May 1, 2024
Accepted: May 21, 2024
Published online: June 27, 2024
Processing time: 124 Days and 13.8 Hours
Revised: May 1, 2024
Accepted: May 21, 2024
Published online: June 27, 2024
Processing time: 124 Days and 13.8 Hours
Core Tip
Core Tip: Split liver transplantation has become a routine procedure at many transplant centers, and there are currently two main approaches for the generation of split-liver allografts: In-situ splitting and ex-vivo splitting. While in-situ splitting, which involves liver division within the organ donor’s body before procurement, is the prevailing technique adopted by most transplant centers, the utilization of ex-vivo splitting, wherein the liver is divided after procurement, remains limited. Our findings suggest that the ex-vivo liver graft splitting technique is a safe and feasible approach, especially under the expertise of an experienced transplant center.