Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2024; 16(6): 1629-1636
Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1629
Gastroesophageal signet ring cell carcinoma morbidity and mortality: A retrospective review
Megan Grinlinton, Chris Furkert, Andrew Maurice, Neville Angelo, Michael Booth
Megan Grinlinton, Chris Furkert, Andrew Maurice, Michael Booth, Department of General Surgery, North Shore Hospital, Auckland 0620, New Zealand
Neville Angelo, Department of Pathology, North Shore Hospital, Auckland 0620, New Zealand
Author contributions: Grinlinton M, Furkert C and Booth M conceptualised and designed the research; Grinlinton M and Angelo N acquired the demographic and clinical data; Furkert C and Grinlinton M collected the clinical data; Maurice A performed data analysis; Grinlinton M wrote the paper; Grinlinton M and Maurice A have played important roles in the data interpretation and manuscript preparation as the authors; Maurice A was instrumental and responsible for data analysis and interpretation; Grinlinton M was responsible for literature search, preparation and submission of the current version of the manuscript. All authors have read and approve the final manuscript.
Institutional review board statement: This study was reviewed and approved by the New Zealand Health and Disability Ethics Committee (No. 15291).
Informed consent statement: Informed consent was not required due to the retrospective and anonymous nature of this study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Megan Grinlinton, FRACS (Gen Surg), MBChB, Doctor, Department of General Surgery, North Shore Hospital, 124 Shakespeare Road, Auckland 0620, New Zealand. megan.grinlinton@gmail.com
Received: January 19, 2024
Revised: April 23, 2024
Accepted: April 28, 2024
Published online: June 27, 2024
Processing time: 162 Days and 5.9 Hours
Core Tip

Core Tip: This retrospective review confirms that in a select group of patients, surgical management for upper gastrointestinal signet ring cell carcinoma may provide a survival benefit and should be considered. Demographic factors such as age, smoking status and gender do not have a relationship with survival. Patients who had surgical management, those with a lower Charlson Comorbidity Index, and those with a lower stage of disease had significantly improved survival.