Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2024; 16(6): 1537-1547
Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1537
Optimal extent of lymphadenectomy improves prognosis and guides adjuvant chemotherapy in esophageal cancer: A propensity score-matched analysis
Ji-Ming Tang, Shu-Jie Huang, Qi-Bin Chen, Han-Sheng Wu, Gui-Bin Qiao
Ji-Ming Tang, Shu-Jie Huang, Qi-Bin Chen, Gui-Bin Qiao, Department of Thoracic Surgery, Guangdong Provincial People’s Hospital, Guangzhou 510080, Guangdong Province, China
Han-Sheng Wu, Department of Thoracic Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Author contributions: Tang JM, Huang SJ, and Chen QB contributed to the conceptualization, data curation, and formal analysis of this study; Tang JM, Huang SJ, Chen QB, and Wu HS were involved in the investigation, methodology of this manuscript; Wu HS contributed to the software, validation, and visualization of this study; Tang JM, Huang SJ, Chen QB, Wu HS, and Qiao GB participated in the writing - original draft, review and editing; Qiao GB contributed to the project administration, resources, and supervision of this study.
Institutional review board statement: The ethics committee of the two hospitals approved our work (No. GDREC2019687H).
Informed consent statement: Written consent was waived due to the retrospective nature of this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The dataset is available from the corresponding author upon reasonable request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gui-Bin Qiao, MD, PhD, Chief Physician, Department of Thoracic Surgery, Guangdong Provincial People’s Hospital, No. 106 Zhongshan Er Road, Yuexiu District, Guangzhou 510080, Guangdong Province, China. guibinqiao@126.com
Received: December 27, 2023
Revised: April 29, 2024
Accepted: May 16, 2024
Published online: June 27, 2024
Processing time: 185 Days and 16.7 Hours
Core Tip

Core Tip: This study delineates the prognostic value of the number of lymph nodes removed during esophagectomy in esophageal squamous cell carcinoma (ESCC) patients, highlighting that a count greater than 21 significantly improves survival outcomes. It introduces a novel prognostic model, incorporating lymph node count with clinical variables, and proposes a nuanced approach to post-operative adjuvant chemotherapy based on lymph node ratio. These insights affirm the importance of extensive lymphadenectomy in ESCC and offer a refined strategy for tailoring adjuvant treatment, thereby enhancing personalized patient care.