Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Feb 27, 2024; 16(2): 276-283
Published online Feb 27, 2024. doi: 10.4240/wjgs.v16.i2.276
Mutational landscape of TP53 and CDH1 in gastric cancer
Hong-Qiao Cai, Li-Yue Zhang, Li-Ming Fu, Bin Xu, Yan Jiao
Hong-Qiao Cai, Yan Jiao, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Li-Yue Zhang, Department of Critical Care Medicine, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Li-Ming Fu, Bin Xu, Department of Traditional Chinese Medicine, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Jiao Y designed the overall concept and outline of the manuscript; Cai HQ contributed to the discussion and design of the manuscript; Zhang LY, Fu LM, and Xu B contributed to the writing, and editing the manuscript, illustrations, and review of literature.
Supported by the Youth Development Fund Task Book of the First Hospital of Jilin University, No. JDYY13202210.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Jiao, MD, PhD, Adjunct Associate Professor, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. lagelangri1@126.com
Received: December 10, 2023
Peer-review started: December 10, 2023
First decision: December 18, 2023
Revised: December 26, 2023
Accepted: January 30, 2024
Article in press: January 30, 2024
Published online: February 27, 2024
Processing time: 77 Days and 13.8 Hours
Core Tip

Core Tip: The separation of TP53 and CDH1 mutations in gastric cancer (GC) demonstrates their separate processes. Mutations in TP53 are linked to advanced-stage cancers and a poor prognosis, whereas CDH1 mutations are linked to widespread GC. This work emphasizes the variability of GC and sheds light on prospective targeted therapeutics based on distinct mutation patterns. Understanding the mutational landscape of TP53 and CDH1 can help to develop tailored therapy strategies for GC patients.