Urgent need for prognostic markers for hepatocellular carcinoma in the light of genomic instability and non-coding RNA signatures

doi:10.4240/wjgs.v16.i10.3087

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Oct 27, 2024 (publication date) through Sep 27, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Oct 27, 2024; 16(10): 3087-3090
Published online Oct 27, 2024. doi: 10.4240/wjgs.v16.i10.3087

Urgent need for prognostic markers for hepatocellular carcinoma in the light of genomic instability and non-coding RNA signatures

Tsvetelina Velikova, Milena Gulinac

Tsvetelina Velikova, Milena Gulinac, Medical Faculty, Sofia University Street Kliment Ohridski, Sofia 1407, Bulgaria

Milena Gulinac, General and Clinical Pathology, Medical University of Plovdiv, Plovdiv 4002, Bulgaria

Co-first authors: Tsvetelina Velikova and Milena Gulinac.

Author contributions: Velikova T and Gulinac M wrote the paper; Velikova T revised the paper. Both authors approved the final version of the manuscript before submission.

Supported by The European Union-Next Generation EU, through the National Recovery and Resilience Plan of the Republic of Bulgaria, No. BG-RRP-2.004-0008.

Conflict-of-interest statement: The authors declare no conflict of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Milena Gulinac, MD, PhD, Academic Research, General and Clinical Pathology, Medical University of Plovdiv, 15A Vassil Aprilov Blvd, Plovdiv 4002, Bulgaria. mgulinac@hotmail.com

Received: April 8, 2024
Revised: May 12, 2024
Accepted: July 8, 2024
Published online: October 27, 2024
Processing time: 172 Days and 7.7 Hours

Core Tip

Core Tip: Despite challenges in diagnosing and treating hepatocellular carcinoma (HCC), identifying suitable prognostic factors is crucial. Duan et al proposed a novel approach using long non-coding RNAs (LncRNAs) to quantify genomic instability (GI) in HCC. Their study demonstrated that the GI-derived LncRNA signature is an independent prognostic factor, outperforming TP53 mutation status alone with an area under the curve of 0.773. These findings underscore the importance of exploring genetic markers for predicting HCC prognosis, aiding in identifying therapeutic targets and improving diagnostic and treatment strategies to alleviate the global burden of this disease.