Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2024; 16(10): 3084-3086
Published online Oct 27, 2024. doi: 10.4240/wjgs.v16.i10.3084
Impact of liver metastasis on immunotherapy in gastric carcinoma
Mushtaq Chalkoo, Mohd Yaqoob Bhat, Yaser Hussain Wani
Mushtaq Chalkoo, Department of Surgery, Government Medical College, Srinagar 190014, Jammu and Kashmir, India
Mohd Yaqoob Bhat, Department of General Surgery, Government Medical College Srinagar, Srinagar 190010, Jammu and Kashmir, India
Yaser Hussain Wani, Post Graduate Department of Minimal Access and General Surgery, Government Medical College Srinagar, Srinagar 190010, Jammu and Kashmīr, India
Co-first authors: Mushtaq Chalkoo and Yaser Hussain Wani.
Author contributions: Chalkoo M, Bhat MY, and Wani YH designed the study; Bhat MY performed the research and typing; Wani YH performed the typing and editing the manuscript as well as analyzed the data; All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Mohd Yaqoob Bhat, MBBS, MS, FNB Minimal Access Surgery Resident, Department of General Surgery, Government Medical College Srinagar, Kaksarai Karan Nagar, Srinagar 190010, Jammu and Kashmir, India. dryaqoob92@gmail.com
Received: March 19, 2024
Revised: May 24, 2024
Accepted: June 28, 2024
Published online: October 27, 2024
Processing time: 192 Days and 19.3 Hours
Core Tip

Core Tip: Liver metastasis affects the systemic immune response, reducing the efficacy of immunotherapy for gastric cancer patients with liver metastases. According to studies, the presence of liver metastases reduces the effectiveness of immunotherapy by lowering progression-free survival and objective response rates. Strategies such as liver-mediated radiation may aid in improving treatment outcomes. Understanding the intricate interplay between the two is crucial for offering the best possible treatment for stomach cancer with liver metastases.