Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2023; 15(9): 2089-2097
Published online Sep 27, 2023. doi: 10.4240/wjgs.v15.i9.2089
Dual transformation therapy for giant hepatocellular carcinoma: Two case reports and review of literature
Qiang Gao, Guang-Zhi Zhu, Chuang-Ye Han, Xin-Ping Ye, Hua-Sheng Huang, Shu-Tian Mo, Tao Peng
Qiang Gao, Guang-Zhi Zhu, Chuang-Ye Han, Xin-Ping Ye, Hua-Sheng Huang, Shu-Tian Mo, Tao Peng, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530000, Guangxi Zhuang Autonomous Region, China
Author contributions: Gao Q, Zhu GZ, and Han CY contributed to data curation and writing of the original draft; Ye XP and Huang HS contributed to data curation; Mo ST, and Peng T contributed to manuscript review and editing; all authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tao Peng, PhD, Chief Doctor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530000, Guangxi Zhuang Autonomous Region, China. pengtaogmu@163.com
Received: May 30, 2023
Peer-review started: May 30, 2023
First decision: July 4, 2023
Revised: July 12, 2023
Accepted: August 1, 2023
Article in press: August 1, 2023
Published online: September 27, 2023
Processing time: 115 Days and 4.8 Hours
Core Tip

Core Tip: There have been many clinical studies on translational therapy for giant hepatocellular carcinoma, but simply seeking surgical transformation always carries the risk of tumor progression. There's a combination of control and transformation in oncology either immunotherapy, targeted therapy, or a combination of both. In addition, we added hepatic arterial infusion chemotherapy to seek better prognosis. In addition to the success of surgical transformation in the 2 patients reported by us, the postoperative pathology also suggested good oncology control and transformation. This treatment regimen is promising to provide more opportunities for radical hepatectomy and better prognosis for patients with large liver cancer.