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World J Gastrointest Surg. Aug 27, 2023; 15(8): 1559-1563
Published online Aug 27, 2023. doi: 10.4240/wjgs.v15.i8.1559
Impact of tumour rupture risk on the oncological rationale for the surgical treatment choice of gastrointestinal stromal tumours
Nadia Peparini
Nadia Peparini, Azienda Sanitaria Locale Roma 6, Ciampino, Rome 00043, Italy
Author contributions: Peparini N conceived and performed research, analized data, wrote and revised the manuscript and gave the final approval.
Conflict-of-interest statement: The author reported no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nadia Peparini, MD, PhD, Azienda Sanitaria Locale Roma 6, Distretto 3, Via Mario Calò 5, Ciampino, Rome 00043, Italy. nadiapeparini@yahoo.it
Received: December 23, 2022
Peer-review started: December 23, 2022
First decision: January 9, 2023
Revised: January 25, 2023
Accepted: June 19, 2023
Article in press: June 19, 2023
Published online: August 27, 2023
Processing time: 244 Days and 21.6 Hours
Core Tip

Core Tip: Tumour rupture is a remarkable risk factor that can change the natural history of low-risk gastrointestinal stromal tumours (GISTs) to a high-risk GIST. This review analyses the concept and prognostic value of tumour rupture in GISTs and highlights the impact of the risk of tumour rupture on the choice of surgical strategy.