Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jul 27, 2023; 15(7): 1532-1541
Published online Jul 27, 2023. doi: 10.4240/wjgs.v15.i7.1532
Idiopathic hypereosinophilic syndrome with hepatic sinusoidal obstruction syndrome: A case report and literature review
Xu-Tao Xu, Bing-Hong Wang, Qiang Wang, Yang-Jie Guo, Yu-Ning Zhang, Xiao-Li Chen, Yan-Fei Fang, Kan Wang, Wen-Hao Guo, Zhen-Zhen Wen
Xu-Tao Xu, Bing-Hong Wang, Yang-Jie Guo, Yu-Ning Zhang, Xiao-Li Chen, Yan-Fei Fang, Kan Wang, Zhen-Zhen Wen, Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Qiang Wang, Department of Hepatopancreatobiliary Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China
Wen-Hao Guo, Department of Pathology, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Author contributions: Xu XT and Wang BH contributed to manuscript writing and editing; Wang Q, Guo YJ and Zhang YN were responsible for data collection; Chen XL, Fang YF and Wang K reviewed the literature; Guo WH contributed to pathological diagnosis; Wen ZZ contributed to conceptualization and supervision; All authors have read and approved the final manuscript to be submitted.
Supported by the National Science of Foundation Committee of Zhejiang Province, No. LY22H160003; and the Zhejiang Provincial Medical and Health Science Foundation; No. 2021441200 and No. 2021RC083.
Informed consent statement: Written informed consent was obtained from the patient for treatment and publication of this case report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read CARE Checklist (2016), and the manuscript was prepared and revised according to CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhen-Zhen Wen, PhD, Associate Chief Physician, Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University, No. 3 East Qingchun Road, Hangzhou 310016, Zhejiang Province, China. 3315019@zju.edu.cn
Received: March 8, 2023
Peer-review started: March 8, 2023
First decision: April 2, 2023
Revised: April 17, 2023
Accepted: May 17, 2023
Article in press: May 17, 2023
Published online: July 27, 2023
Core Tip

Core Tip: Idiopathic hypereosinophilic syndrome (IHES) is characterized by a continuous increase and abnormal accumulation of eosinophils in the peripheral blood. Its clinical manifestations vary, and may involve multiple organs and cause serious damage. Hepatic sinusoidal obstruction syndrome (HSOS) can lead to veno-occlusion and hepatocyte necrosis. We report a case of IHES with HSOS. However, the cause of HSOS was unknown, and we could not determine whether it was caused by herbal medicine or IHES. Prednisone, low molecular weight heparin and ursodeoxycholic acid were given. Hypereosinophilia may play a facilitating role in the occurrence and development of HSOS.