Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2023; 15(6): 1169-1177
Published online Jun 27, 2023. doi: 10.4240/wjgs.v15.i6.1169
Published online Jun 27, 2023. doi: 10.4240/wjgs.v15.i6.1169
Influences of dexmedetomidine on stress responses and postoperative cognitive and coagulation functions in patients undergoing radical gastrectomy under general anesthesia
Xiang-Fei Ma, Shi-Jia Lv, Shen-Qiao Wei, Bing-Rong Mao, Xiu-Xia Zhao, Xiao-Qing Jiang, Fei Zeng, Xue-Ke Du, Department of Anesthesiology, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, Guangxi Zhuang Autonomous Region, China
Author contributions: Ma XF proposed the overall research goal and designed the research plan and model design; Ma XF, Lv SJ, Wei SQ and Mao BR conducted feasibility analysis, review and supervision of the experiment; Du XK, Zhao XX, and Jiang XQ collected clinical data; Ma XF, Zhao XX, and Zeng F conducted statistical processing and analysis of the data; Ma XF and Du XK are responsible for writing the first draft of the paper; Ma XF is responsible for the review, revision and quality control of the paper; all authors determined the final draft of the paper.
Supported by Project of Guangxi Health and Health Commission , No. Z20201268 .
Institutional review board statement: The study was reviewed and approved by The Second Affiliated Hospital of Guangxi Medical University Institutional Review Board [Approval No. 2020(KY-0141)].
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no competing interests.
Data sharing statement: The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Ke Du, DSc, Medical Assistant, Department of anesthesiology, The second affiliated hospital of guangxi medical university, No. 166 Daxuedong Road, Nanning 530007, Guangxi Zhuang Autonomous Region, China. mxf17031861@126.com
Received: March 6, 2023
Peer-review started: March 6, 2023
First decision: March 14, 2023
Revised: March 22, 2023
Accepted: April 19, 2023
Article in press: April 19, 2023
Published online: June 27, 2023
Processing time: 101 Days and 4 Hours
Peer-review started: March 6, 2023
First decision: March 14, 2023
Revised: March 22, 2023
Accepted: April 19, 2023
Article in press: April 19, 2023
Published online: June 27, 2023
Processing time: 101 Days and 4 Hours
Core Tip
Core Tip: Radical gastrectomy (RG), a minimally invasive procedure, is reported to be the optimal cure for gastric cancer (GC) with the advantages of lesser pain and faster recovery. Dexmedetomidine (DEX) is used in a wide range of clinical scenarios. Available evidence suggests that DEX can reduce perioperative inflammation and stress and exert a certain protective effect on cognitive function (CF) in elderly patients after laparoscopic cholecystectomy. In this study, we aimed to assess the influence of DEX on stress responses, CF, and coagulation function of GC patients undergoing RG under general anesthesia, with a view to contributing to the improvement of prognosis in these patients.