Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Apr 27, 2023; 15(4): 723-739
Published online Apr 27, 2023. doi: 10.4240/wjgs.v15.i4.723
Published online Apr 27, 2023. doi: 10.4240/wjgs.v15.i4.723
The global epidemiology of upper and lower gastrointestinal bleeding in general population: A systematic review
Şiir Su Saydam, Megan Molnar, Pareen Vora, Integrated Evidence Generation, Bayer AG, Berlin 13353, Germany
Author contributions: Saydam SS and Vora P designed the research study; Saydam SS, Molnar M and Vora P performed the research; Saydam SS analyzed the data and wrote the manuscript; All authors have read and approved the final manuscript.
Conflict-of-interest statement: Saydam SS and Vora P are employees of Bayer AG. Molnar M was an employee of Bayer AG at the time the study was carried out.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pareen Vora, PhD, Director, Integrated Evidence Generation, Bayer AG, Muellerstr. 178, Berlin 13353, Germany. pareen.vora@bayer.com
Received: October 19, 2022
Peer-review started: October 19, 2022
First decision: January 3, 2023
Revised: January 20, 2023
Accepted: March 8, 2023
Article in press: March 8, 2023
Published online: April 27, 2023
Processing time: 185 Days and 16.3 Hours
Peer-review started: October 19, 2022
First decision: January 3, 2023
Revised: January 20, 2023
Accepted: March 8, 2023
Article in press: March 8, 2023
Published online: April 27, 2023
Processing time: 185 Days and 16.3 Hours
Core Tip
Core Tip: This review addresses an important literature gap in summarizing the long-term global epidemiology of GIB. Epidemiological data were more widely available for UGIB than for LGIB, which were limited. Estimates of GIB were highly heterogeneous, often due to differences in case definitions, but showed a decreasing trend for UGIB incidence.