Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Apr 27, 2023; 15(4): 643-654
Published online Apr 27, 2023. doi: 10.4240/wjgs.v15.i4.643
Risk factors for blood transfusion and its prognostic implications in curative gastrectomy for gastric cancer
Lucas Eiki Kawakami, Pedro Barzan Bonomi, Marina Alessandra Pereira, Fabrício Oliveira Carvalho, Ulysses Ribeiro Jr, Bruno Zilberstein, Luciana Ribeiro Sampaio, Luiz Augusto Carneiro-D'Albuquerque, Marcus Fernando Kodama Pertille Ramos
Lucas Eiki Kawakami, Pedro Barzan Bonomi, Marina Alessandra Pereira, Ulysses Ribeiro Jr, Bruno Zilberstein, Luiz Augusto Carneiro-D'Albuquerque, Marcus Fernando Kodama Pertille Ramos, Department of Gastroenterology, Instituto do Cancer, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 01249000, Brazil
Fabrício Oliveira Carvalho, Luciana Ribeiro Sampaio, Blood Transfusion Unit, Instituto do Cancer, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo 01249000, Brazil
Author contributions: Kawakami LE and Bonomi PB contributed to data retrieval, critical analysis, and manuscript drafting; Pereira MA contributed to data retrieval, critical analysis, statistical analysis, and manuscript review; Carvalho FO and Sampaio LR contributed to data retrieval and manuscript review; Ribeiro Jr. U, Zilberstein B, and Carneiro-D'Albuquerque LA contributed to critical analysis and manuscript review; Ramos MFKP contributed to study design, data retrieval, critical analysis, and manuscript drafting.
Institutional review board statement: The study was approved by the Hospital Ethics Committee and registered online (https://plataformabrasil.saude.gov.br; CAAE: 59337222.7.0000.0068).
Informed consent statement: Informed consent was waived by the local ethics committee, given the study's retrospective nature.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marcus Fernando Kodama Pertille Ramos, PhD, Doctor, Surgical Oncologist, Department of Gastroenterology, Instituto do Cancer, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av Dr Arnaldo, 251, Sao Paulo 01249000, Brazil. marcus.kodama@hc.fm.usp.br
Received: December 23, 2022
Peer-review started: December 23, 2022
First decision: February 3, 2023
Revised: February 12, 2023
Accepted: March 30, 2023
Article in press: March 30, 2023
Published online: April 27, 2023
Processing time: 120 Days and 20.1 Hours
Core Tip

Core Tip: This is a retrospective study to investigate the association of perioperative red blood cell (RBC) transfusion with surgical and survival outcomes in patients with gastric cancer. Our findings demonstrated that patients who received RBC transfusion had poorer preoperative clinical conditions and more aggressive tumors, and were submitted to more invasive procedures. The rates of postoperative complications and 30-d and 90-d mortality were also significantly higher in patients who received RBC transfusions compared to those who did. Further, receiving an RBC transfusion was an independent factor associated with worse survival.