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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Apr 27, 2023; 15(4): 495-519
Published online Apr 27, 2023. doi: 10.4240/wjgs.v15.i4.495
Published online Apr 27, 2023. doi: 10.4240/wjgs.v15.i4.495
Current and emerging therapeutic approaches for colorectal cancer: A comprehensive review
Anil Kumar, Vipasha Gautam, Arushi Sandhu, Kajal Rawat, Antika Sharma, Lekha Saha, Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
Author contributions: Kumar A performed the conceptualization, wrote the original draft preparation, and contributed to software, visualization and investigation, and reviewing and editing; Gautam V, Sandhu A, and Sharma A wrote the original draft preparation; Rawat K wrote the original draft preparation and performed the proofreading; Saha L contributed to the conceptualization, supervision, and reviewing and editing.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lekha Saha, MBBS, MD, MNAMS, Full Professor, Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Research Block B, Chandigarh 160012, India. lekhasaha@rediffmail.com
Received: October 21, 2022
Peer-review started: October 21, 2022
First decision: January 3, 2023
Revised: January 11, 2023
Accepted: March 3, 2023
Article in press: March 3, 2023
Published online: April 27, 2023
Processing time: 183 Days and 22.9 Hours
Peer-review started: October 21, 2022
First decision: January 3, 2023
Revised: January 11, 2023
Accepted: March 3, 2023
Article in press: March 3, 2023
Published online: April 27, 2023
Processing time: 183 Days and 22.9 Hours
Core Tip
Core Tip: This review highlights some of the latest colorectal cancer treatment approaches that have the potential to soon translate into standard care. A vast literature of patient data has revealed that conventional therapies are non-specific and have numerous secondary complications. Additionally, patients develop resistance to conventional chemotherapies. There is a need to develop new target-specific arrows in the cancer-fighting quiver.