Systematic Reviews
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World J Gastrointest Surg. Feb 27, 2023; 15(2): 249-257
Published online Feb 27, 2023. doi: 10.4240/wjgs.v15.i2.249
Hypophosphatemia as a prognostic tool for post-hepatectomy liver failure: A systematic review
Romualdas Riauka, Povilas Ignatavicius, Giedrius Barauskas
Romualdas Riauka, Povilas Ignatavicius, Giedrius Barauskas, Department of Surgery, Lithuanian University of Health Sciences, Kaunas 50161, Lithuania
Author contributions: Riauka R, Ignatavicius P and Barauskas G contributed to study design and conception, data collection, analysis and interpretation and writing the draft of the manuscript; and all authors read and approved the published version of the manuscript.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Povilas Ignatavicius, MD, PhD, Academic Research, Doctor, Lecturer, Surgeon, Department of Surgery, Lithuanian University of Health Sciences, Eiveniu 2, Kaunas 50161, Lithuania. povilas.ignatavicius@lsmuni.lt
Received: July 19, 2022
Peer-review started: July 19, 2022
First decision: August 19, 2022
Revised: September 1, 2022
Accepted: November 28, 2022
Article in press: November 28, 2022
Published online: February 27, 2023
Processing time: 222 Days and 18.1 Hours
Core Tip

Core Tip: A systematic literature review on hypophosphatemia and its value as a prognostic factor for post-hepatectomy liver failure and overall morbidity after liver surgery was performed. In three of nine included studies hypophosphatemia was associated with better postoperative outcomes, while six studies revealed hypophosphatemia as a predictive factor for worse patient outcomes. Data show that postoperative hypophosphatemia and changes of postoperative serum phosphorus might be used as a predictor after liver surgery. However, to be implemented in clinical practice as routine measurement more studies and data are needed.