Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2023; 15(12): 2774-2782
Published online Dec 27, 2023. doi: 10.4240/wjgs.v15.i12.2774
Effects of remifentanil combined with propofol on hemodynamics and oxidative stress in patients undergoing resection of rectal carcinoma
Jing Huang, Wen-Jun Tian
Jing Huang, Department of First Anesthesiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Wen-Jun Tian, Department of Fourth Anesthesiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Author contributions: Huang J and Tian WJ contributed to the experimental design and implementation; Huang J contributed to the data curation; Huang J and Tian WJ contributed to the writing-original draft preparation and writing-review and editing; all authors have reviewed and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Dalian Medical University.
Informed consent statement: This reaearch is a retrospective study that only used anonymous patient data from the hospital system for analysis, and will not cause any adverse harm to patients. We have applied to the hospital ethics committee for exemption from the patient's informed consent form.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Jun Tian, MM, Attending Doctor, Department of Fourth Anesthesiology, the First Affiliated Hospital of Dalian Medical University, No. 193 Shahekou District, Dalian 116011, Liaoning Province, China. wenjun8907@163.com
Received: October 23, 2023
Peer-review started: October 23, 2023
First decision: November 8, 2023
Revised: November 20, 2023
Accepted: December 1, 2023
Article in press: December 1, 2023
Published online: December 27, 2023
Processing time: 65 Days and 9.9 Hours
Core Tip

Core Tip: This study evaluated the effects of remifentanil combined with propofol on the hemodynamics and oxidative stress in patients undergoing rectal carcinoma surgery. These findings indicate that this combination improves hemodynamic stability, reduces oxidative stress, and results in a lower incidence of hypotension compared with sufentanil alone. Furthermore, the remifentanil-propofol combination requires less remifentanil consumption and reduced use of ephedrine, suggesting that it is a more effective and potentially safer anesthetic approach for these surgeries.