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World J Gastrointest Surg. Dec 27, 2023; 15(12): 2693-2708
Published online Dec 27, 2023. doi: 10.4240/wjgs.v15.i12.2693
Indocyanine green fluorescence in gastrointestinal surgery: Appraisal of current evidence
Raja Kalayarasan, Murugesan Chandrasekar, Pothugunta Sai Krishna, Dasarathan Shanmugam
Raja Kalayarasan, Murugesan Chandrasekar, Pothugunta Sai Krishna, Dasarathan Shanmugam, Department of Surgical Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India
Author contributions: Kalayarasan R and Chandrasekar M conceptualized the work, supervised the writing, gave intellectual inputs, and critically revised the manuscript; Sai Krishna P and Shanmugam D did the literature search and wrote the first draft of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Raja Kalayarasan, FRCS (Ed), MBBS, MCh, MS, Additional Professor, Department of Surgical Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantari nagar, Puducherry 605006, India. kalayarasanraja@yahoo.com
Received: July 19, 2023
Peer-review started: July 19, 2023
First decision: October 9, 2023
Revised: October 12, 2023
Accepted: November 9, 2023
Article in press: November 9, 2023
Published online: December 27, 2023
Processing time: 160 Days and 18.3 Hours
Core Tip

Core Tip: Indocyanine green (ICG)’s unique absorption and emission spectrum allows its wide application in gastrointestinal surgery. The fluorescence cholangiography property of ICG is widely used in hepatobiliary surgery to identify bile ducts. Its angiography property is used in liver surgery for tumor identification and to facilitate anatomic liver resection. Also, the angiography function is helpful in luminal surgeries to assess bowel perfusion. The limitations of ICG fluorescence highlighted in the present review could guide future research on ICG in gastrointestinal surgery.