Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2023; 15(11): 2646-2656
Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2646
Comprehensive treatment and a rare presentation of Cronkhite–Canada syndrome: Two case reports and review of literature
Yan-Qing Lv, Mei-Lan Wang, Tong-Yu Tang, Yu-Qin Li
Yan-Qing Lv, Department of Hepatobiliary and Pancreatic Medicine, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Mei-Lan Wang, Department of Gastroenterology, Jilin Provincial People's Hospital, Changchun 130021, Jilin Province, China
Tong-Yu Tang, Yu-Qin Li, Department of Gastroenterology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Lv YQ collected and sorted out the cases, reviewed the literature, and wrote the manuscript; Wang ML reviewed the literature; Tang TY contributed to the content and editing of the manuscript; Li YQ reviewed and revised the manuscript; All authors have read and approved the final manuscript.
Supported by Jilin Provincial Science and Technology Department Project, No. 20200201343JC; and Science and Technology Development Program of Jilin Province, No. 20210402013GH.
Informed consent statement: This study was approved by the Ethics Committee of the First Bethune Hospital of Jilin University to waive informed written consent about personal and medical data collection.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Qin Li, MD, Chief Physician, Professor, Department of Gastroenterology, The First Hospital of Jilin University, No. 71 Xinmin Street, Changchun 130021, Jilin Province, China. liyuq@jlu.edu.cn
Received: August 15, 2023
Peer-review started: August 15, 2023
First decision: September 1, 2023
Revised: September 15, 2023
Accepted: October 17, 2023
Article in press: October 17, 2023
Published online: November 27, 2023
Core Tip

Core Tip: Cronkhite–Canada syndrome (CCS) is a rare, non-genetic syndrome characterized by ectodermal abnormalities and diffuse gastrointestinal polyps with protein loss. To date, 7 patients with CCS combined with hypothyroidism have been identified. We report two cases, one of which is combined with hypothyroidism. Through indexing and analyzing PubMed, Web of Science, and Embase databases, we summarized the clinical characteristics of CCS combined with hypothyroidism. Additionally, we concluded that pharmacotherapy can induce and maintain remission in CCS patients, with adjuvant endoscopic mucosal resection, long-term follow-up, and endoscopic surveillance being necessary.