Mowlah RK, Soldera J. Risk and management of post-operative infectious complications in inflammatory bowel disease: A systematic review. World J Gastrointest Surg 2023; 15(11): 2579-2595 [PMID: 38111772 DOI: 10.4240/wjgs.v15.i11.2579]
Corresponding Author of This Article
Jonathan Soldera, MD, MSc, Tutor, Acute Medicine, University of South Wales, Llantwit Road, Pontypridd, Cardiff CF37 1DL, United Kingdom. jonathansoldera@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Nov 27, 2023; 15(11): 2579-2595 Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2579
Risk and management of post-operative infectious complications in inflammatory bowel disease: A systematic review
Reshma Kureemun Mowlah, Jonathan Soldera
Reshma Kureemun Mowlah, Jonathan Soldera, Acute Medicine, University of South Wales, Cardiff CF37 1DL, United Kingdom
Author contributions: Mowlah RK and Soldera J participated in the concept and design of the research, drafted the manuscript and contributed to data acquisition, analysis and interpretation; Soldera J contributed to study supervision; all authors contributed to critical revision of the manuscript for important intellectual content.
Conflict-of-interest statement: The authors have no conflict of interest to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jonathan Soldera, MD, MSc, Tutor, Acute Medicine, University of South Wales, Llantwit Road, Pontypridd, Cardiff CF37 1DL, United Kingdom. jonathansoldera@gmail.com
Received: July 17, 2023 Peer-review started: July 17, 2023 First decision: August 8, 2023 Revised: August 13, 2023 Accepted: October 27, 2023 Article in press: October 27, 2023 Published online: November 27, 2023 Processing time: 133 Days and 8.7 Hours
Core Tip
Core Tip: This paper highlights the risk factors associated with post-operative infectious complications in patients with inflammatory bowel disease (IBD) undergoing abdominal surgery and explores management strategies to reduce morbidity and mortality. Key findings include the association of hypoalbuminemia, malnutrition, preoperative abscess, obesity, and perioperative blood transfusion with increased infectious complications. Corticosteroids were found to be a risk factor, while medications such as 5-aminosalicylates and immunomodulators did not increase complications. Ustekinumab and vedolizumab showed comparable rates of infectious complications to other treatments. The impact of minimally invasive surgery on complications varied. This paper emphasizes the importance of a comprehensive approach involving multiple disciplines to mitigate post-operative infections in IBD patients. Understanding these risk factors and implementing appropriate management strategies can improve outcomes in this patient population.
