Case Report
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2023; 15(10): 2357-2361
Published online Oct 27, 2023. doi: 10.4240/wjgs.v15.i10.2357
Gastric adenosquamous carcinoma with an elevated serum level of alpha-fetoprotein: A case report
Liang Sun, Juan-Juan Wei, Ran An, Hui-Yun Cai, Yuan Lv, Tao Li, Xiao-Fei Shen, Jun-Feng Du, Gang Chen
Liang Sun, Hui-Yun Cai, Yuan Lv, Tao Li, Xiao-Fei Shen, Jun-Feng Du, Gang Chen, Department of General Surgery, The 7th Medical Center of PLA General Hospital, Beijing 100700, China
Juan-Juan Wei, Operating Room, Department of Anesthesiology, The 7th Medical Center of PLA General Hospital, Beijing 100700, China
Ran An, Department of Pathology, The 7th Medical Center of PLA General Hospital, Beijing 100700, China
Author contributions: Sun L and Wei JJ contributed equally to this work, contributed to the conceptualization and writing-original draft; An R, Cai HY, Li T, Lv Y and Shen XF provided technical support for the staining of the sections and performed standard pathologic analysis; Du JF and Chen G involved in the writing-review and editing; the work reported in the article has been performed by the authors, unless clearly specified in the text; and all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81970500, 81571563 and 81870393.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised in accordance with it.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gang Chen, MD, PhD, Adjunct Professor, Chief Doctor, Department of General Surgery, The 7th Medical Center of PLA General Hospital, No. 5 NanmenCang, Beijing 100700, China. chengang@301hospital.com.cn
Received: June 16, 2023
Peer-review started: June 16, 2023
First decision: July 23, 2023
Revised: July 29, 2023
Accepted: August 18, 2023
Article in press: August 18, 2023
Published online: October 27, 2023
Processing time: 133 Days and 6.2 Hours
Core Tip

Core Tip: Most patients diagnosed with gastric cancer (GC) have a pathological phenotype of adenocarcinoma, and gastric adenosquamous carcinoma (ASC) is rare. We presented a rare case of gastric ASC with elevated serum alpha-fetoprotein (AFP) level, which may be new subtype of AFP-producing GC. AFP-GC is an aggressive cancer with high incidence of liver or lymph node metastasis. Follow-up detection of serum AFP might be a useful tool to predict prognosis.