Meta-Analysis
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2023; 15(10): 2331-2342
Published online Oct 27, 2023. doi: 10.4240/wjgs.v15.i10.2331
Bariatric surgery reduces colorectal cancer incidence in obese individuals: Systematic review and meta-analysis
Ying-Ning Liu, Jing-Feng Gu, Jian Zhang, Dong-Yang Xing, Gui-Qi Wang
Ying-Ning Liu, Jing-Feng Gu, Jian Zhang, Dong-Yang Xing, Gui-Qi Wang, Department of Gastrointestinal Surgery, The First Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Author contributions: Liu YN and Gu JF contributed to the conception of the study; Zhang J and Liu YN contributed significantly to literature search, data extraction, quality assessment, data analyses and manuscript preparation; Xing DY contributed improving the article for language and style and protocol preparation; Gu JF helped perform the analysis with constructive discussions; Wang GQ revised the manuscript and approved the final version.
Conflict-of-interest statement: The authors Ying-Ning Liu, Jing-Feng Gu, Jian Zhang, Dong-Yang Xing and Gui-Qi Wang all declare that there are no conflicts of interest related to this study.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gui-Qi Wang, MM, Chief Doctor, Department of Gastrointestinal Surgery, The First Hospital of Hebei Medical University, No. 89 Donggang Road, Shijiazhuang 050011, Hebei Province, China. doc_wangguiqi@163.com
Received: July 9, 2023
Peer-review started: July 9, 2023
First decision: August 10, 2023
Revised: August 14, 2023
Accepted: August 21, 2023
Article in press: August 21, 2023
Published online: October 27, 2023
Processing time: 110 Days and 1.6 Hours
Core Tip

Core Tip: This comprehensive meta-analysis evaluates the impact of bariatric surgery on colorectal cancer (CRC) risk using 17 studies with over 12 million patients. Results show a 54% reduction in CRC risk after surgery, with women experiencing a 46% decrease. Interestingly, the type of bariatric surgery, whether Sleeve Gastrectomy or Roux-en-Y Gastric Bypass, did not influence this risk reduction. Bariatric procedures underscore a pivotal role in managing CRC risk in the obese. The study highlights the surgery's protective effect, especially for women, and the need for further research on potential confounding factors.