Luo J, He MW, Luo T, Lv GQ. Identification of multiple risk factors for colorectal cancer relapse after laparoscopic radical resection. World J Gastrointest Surg 2023; 15(10): 2211-2221 [PMID: 37969700 DOI: 10.4240/wjgs.v15.i10.2211]
Corresponding Author of This Article
Guo-Qing Lv, MS, Attending Doctor, Department of Gastrointestinal Surgery, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Peking University Shenzhen Hospital, No. 120 Lianhua Road, Futian District, Shenzhen 518036, Guangdong Province, China. 365973269@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Oct 27, 2023; 15(10): 2211-2221 Published online Oct 27, 2023. doi: 10.4240/wjgs.v15.i10.2211
Identification of multiple risk factors for colorectal cancer relapse after laparoscopic radical resection
Jun Luo, Mei-Wen He, Ting Luo, Guo-Qing Lv
Jun Luo, Mei-Wen He, Department of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Ting Luo, Department of Operating Room, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Guo-Qing Lv, Department of Gastrointestinal Surgery, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Author contributions: Luo J proposed the concept of this study; He MW contributed to data collection; Luo J and Luo T contributed to formal analysis; Lv GQ participated in the survey; Luo T contributed to these methods; Lv GQ, He MW, and Luo J guided the research; Lv GQ validated this study; Luo J contributed to the visualization of this study; Luo J wrote the first draft; All authors reviewed and edited the manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Shenzhen University Hospital.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Qing Lv, MS, Attending Doctor, Department of Gastrointestinal Surgery, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Peking University Shenzhen Hospital, No. 120 Lianhua Road, Futian District, Shenzhen 518036, Guangdong Province, China. 365973269@qq.com
Received: July 18, 2023 Peer-review started: July 18, 2023 First decision: August 4, 2023 Revised: August 8, 2023 Accepted: August 18, 2023 Article in press: August 18, 2023 Published online: October 27, 2023 Processing time: 101 Days and 1.7 Hours
Core Tip
Core Tip: This study aimed to identify the risk factors for colorectal cancer (CRC) relapse after laparoscopic radical resection by comparing the baseline data and laboratory indicators of 140 patients with CRC, of whom 30 patients experienced relapse within 3 years. Rectal tumors with low differentiation and lymphatic vessel invasion were associated with higher relapse rates. Lower CD4+/CD8+ ratio, immunoglobulins (Ig) IgA, IgG, IgM, albumin-globulin ratio, and prognostic nutritional index and higher neutrophils to lymphocytes ratio, cytokeratin 19 fragment antigen 21-1, vascular endothelial growth factor, and Chitinase-3-like protein 1 were also identified as independent risk factors for CRC relapse following surgery. These findings suggested that monitoring these factors could reduce the risk of disease recurrence and improve patient outcomes.
