Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2023; 15(1): 82-93
Published online Jan 27, 2023. doi: 10.4240/wjgs.v15.i1.82
Effects of postoperative use of proton pump inhibitors on gastrointestinal bleeding after endoscopic variceal treatment during hospitalization
Yi-Yan Zhang, Le Wang, Xiao-Dong Shao, Yong-Guo Zhang, Shao-Ze Ma, Meng-Yuan Peng, Shi-Xue Xu, Yue Yin, Xiao-Zhong Guo, Xing-Shun Qi
Yi-Yan Zhang, Le Wang, Xiao-Dong Shao, Yong-Guo Zhang, Shao-Ze Ma, Meng-Yuan Peng, Shi-Xue Xu, Yue Yin, Xiao-Zhong Guo, Xing-Shun Qi, Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Northern Theater Command, Shenyang 110840, Liaoning Province, China
Yi-Yan Zhang, Le Wang, Shi-Xue Xu, Yue Yin, Postgraduate College, China Medical University, Shenyang 110122, Liaoning Province, China
Shao-Ze Ma, Postgraduate College, Dalian Medical University, Dalian 116044, Liaoning Province, China
Author contributions: Qi XS contributed to conceptualization; Zhang YY, Wang L, Shao XD, Zhang YG, Ma SZ, Peng MY, Xu SX, Yin Y, Guo XZ, and Qi XS contributed to methodology; Zhang YY and Qi XS contributed to formal analysis; Zhang YY, Wang L, Shao XD, Zhang YG, Ma SZ, Peng MY, Xu SX, Yin Y, Guo XZ, and Qi XS contributed to data curation; Zhang YY and Qi XS contributed to writing original draft; Zhang YY, Wang L, Shao XD, Zhang YG, Ma SZ, Peng MY, Xu SX, Yin Y, Guo XZ, and Qi XS contributed to writing review and editing; Guo XZ and Qi XS contributed to supervision; Qi XS contributed to project administration; all authors have read and approved the final manuscript.
Institutional review board statement: This study has been approved by the Medical Ethical Committee of the General Hospital of Northern Theater Command with an approval number [Y (2022) 072] and was performed according to the Declaration of Helsinki.
Informed consent statement: The requirement for patients' informed consent for this study was waived due to its retrospective nature.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The dataset of the current study is available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xing-Shun Qi, MD, PhD, Associate Professor, Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenyang 110840, Liaoning Province, China. xingshunqi@126.com
Received: July 25, 2022
Peer-review started: July 25, 2022
First decision: September 26, 2022
Revised: October 11, 2022
Accepted: November 7, 2022
Article in press: November 7, 2022
Published online: January 27, 2023
Processing time: 176 Days and 16.7 Hours
Core Tip

Core Tip: The role of proton pump inhibitors (PPIs) in the management of post-endoscopic variceal treatment (EVT) complications remains controversial. We conducted a retrospective study to explore the effects of postoperative use of PPIs on post-EVT gastrointestinal bleeding (GIB) and other post-EVT complications in patients with liver cirrhosis during hospitalization. We found that postoperative use of PPIs was not beneficial for reducing the development of post-EVT GIB and other post-EVT complications during hospitalization. Collectively, routine use of PPIs after EVT during hospitalization may not be recommended, and their indications should be carefully evaluated.