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World J Gastrointest Surg. May 27, 2022; 14(5): 383-396
Published online May 27, 2022. doi: 10.4240/wjgs.v14.i5.383
Recent advances in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasms
Meng Dai, Christina S Mullins, Lili Lu, Guido Alsfasser, Michael Linnebacher
Meng Dai, Christina S Mullins, Lili Lu, Michael Linnebacher, Clinic of General Surgery, Molecular Oncology and Immunotherapy, Rostock University Medical Center, 18057 Rostock, Germany
Guido Alsfasser, Clinic of General Surgery, Rostock University Medical Center, 18057 Rostock, Germany
Author contributions: Dai M and Linnebacher M analyzed the literature and wrote the manuscript; Alsfasser G, Lu L and Mullins CS critically reviewed the manuscript; Mullins CS edited the language as a native speaker.
Supported by China Scholarship Council, No. 202108080085 to (Dai M) and No. 201908080127 to (Lu LL).
Conflict-of-interest statement: None to be declared.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Michael Linnebacher, PhD, Academic Fellow, Research Fellow, Research Scientist, Senior Researcher, Senior Scientist, Clinic of General Surgery, Molecular Oncology and Immunotherapy, Rostock University Medical Center, Schillingallee 35, Rostock 18057, Mecklenburg-Vorpommern, Germany. michael.linnebacher@med.uni-rostock.de
Received: November 10, 2021
Peer-review started: November 10, 2021
First decision: January 9, 2022
Revised: January 17, 2022
Accepted: April 29, 2022
Article in press: April 29, 2022
Published online: May 27, 2022
Processing time: 195 Days and 20.1 Hours
Core Tip

Core Tip: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a group of heterogeneous tumors arising from neuroendocrine cells of the digestive system. Researchers have achieved great improvements in diagnosis and treatment. This includes improved grading, identification of specific genetic mutations, functional imaging, and broad application of peptide receptor radionuclide therapy. Here, we systematically summarized the latest progress in diagnosis and treatment of GEP-NENs, thereby providing guidance for clinicians active in this field.