Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2022; 14(1): 64-77
Published online Jan 27, 2022. doi: 10.4240/wjgs.v14.i1.64
Routine laboratory parameters in patients with necrotizing pancreatitis by the time of operative pancreatic debridement: Food for thought
Yaroslav M Susak, Kristina Opalchuk, Olexandr Tkachenko, Mariia Rudyk, Larysa Skivka
Yaroslav M Susak, Department of Surgery with the Course of Emergency and Vascular Surgery, O.O. Bogomolet’s National Medical University, Kyiv 01601, Ukraine
Kristina Opalchuk, Department of Surgery, Anesthesiology and Intensive Care Postgraduate Education, O.O. Bogomolet’s National Medical University, Kyiv 01601, Ukraine
Olexandr Tkachenko, Department of Surgery N2, Kyiv City Clinical Emergency Hospital, Kyiv City Clinical Emergency Hospital, Kyiv 02000, Ukraine
Mariia Rudyk, Larysa Skivka, Department of Microbiology and Immunology, Educational and Scientific Center “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, Kyiv 01033, Ukraine
Author contributions: Susak YM was chief surgeon and performed the surgeries on patients included in this study; Opalchuk K was a surgeon and assisted with surgeries on patients who are included in this study and was involved with data collection; Tkachenko O was a supervisor and participated in design of the study; Rudyk M assisted with statistical analysis of the data; Skivka L drafted the manuscript, performed statistical analysis, and participated in design of the study; All authors have read and approved the final manuscript.
Institutional review board statement: The project has been reviewed and approved by the Committee on Human Rights Related to Research Involving Human Subjects of Kyiv City Clinical Emergency Hospital (Kyiv, Ukraine), based on the Declaration of Helsinki.
Informed consent statement: All subjects gave their written informed consent prior to study inclusion.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: There is no additional data available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mariia Rudyk, PhD, Associate Professor, Department of Microbiology and Immunology, Educational and Scientific Center “Institute of Biology and Medicine”, Taras Shevchenko National University of Kyiv, 2 Hlushkova Avenue, Kyiv 03127, Ukraine. rosiente@gmail.com
Received: May 18, 2021
Peer-review started: May 18, 2021
First decision: June 15, 2021
Revised: June 29, 2021
Accepted: December 22, 2021
Article in press: December 22, 2021
Published online: January 27, 2022
Processing time: 245 Days and 18.7 Hours
Core Tip

Core Tip: This is a retrospective study to evaluate laboratory variables in patients with acute necrotizing pancreatitis in the preoperative period for their use in the timing of operative pancreatic debridement (OPD). We demonstrated that progressive increase in platelet counts correlate with shortened length of hospital stay. It can indicate granulation tissue formation, and can be considered as an additional marker for OPD timing. Persistent hepatic malfunction, which is indicated by a weak progressive decrease of the direct bilirubin and increased aspartate aminotransferase level can signify a high risk of post-operative mortality. Multifactorial analysis of dynamic changes of laboratory variables can be useful for person-tailored timing of OPD.