Meta-Analysis
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Sep 27, 2021; 13(9): 1079-1094
Published online Sep 27, 2021. doi: 10.4240/wjgs.v13.i9.1079
Perioperative steroid administration reduces overall complications in patients undergoing liver resection: A meta-analysis
Hao-Han Hai, Phoebe Aw, Thomas Zheng Jie Teng, Vishal G Shelat
Hao-Han Hai, Phoebe Aw, NUS Yong Loo Lin School of Medicine, Singapore 119228, Singapore
Thomas Zheng Jie Teng, Vishal G Shelat, NTU Lee Kong Chian School of Medicine, Singapore 308232, Singapore
Vishal G Shelat, Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore
Author contributions: Hai HH and Aw P performed the analysis of the results and writing of the manuscript; Teng TZJ contributed to editing the manuscript and interpreting the results; Shelat VG designed and directed the project; All authors discussed the results and commented on the manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vishal G Shelat, FRCS (Ed), FEBS, Adjunct Associate Professor, Department of General Surgery, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore 308433, Singapore. vgshelat@gmail.com
Received: January 26, 2021
Peer-review started: January 26, 2021
First decision: March 29, 2021
Revised: April 3, 2021
Accepted: June 16, 2021
Article in press: June 16, 2021
Published online: September 27, 2021
Processing time: 234 Days and 23.8 Hours
Core Tip

Core Tip: Hepatic resection results in an inflammatory response that can be modified by perioperative steroid administration. However, it remains to be determined if this response's attenuation translates to a reduction in complications. This systematic review compares eight randomized controlled trials including 590 patients. We found that perioperative steroid administration was associated with a significant reduction in postoperative complications. There was also improvement in biochemical and inflammatory markers.