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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Feb 27, 2021; 13(2): 187-197
Published online Feb 27, 2021. doi: 10.4240/wjgs.v13.i2.187
Published online Feb 27, 2021. doi: 10.4240/wjgs.v13.i2.187
Perianal fistulodesis – A pilot study of a novel minimally invasive surgical and medical approach for closure of perianal fistulae
Roxanne Villiger, Pascal Frei, Luc Biedermann, Christian Schneider, Gerhard Rogler, Benjamin Misselwitz, Department of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich 8091, Switzerland
Daniela Cabalzar-Wondberg, Matthias Turina, Andreas Rickenbacher, Visceral- and Transplant Surgery, University Hospital of Zurich, Zurich 8091, Switzerland
Daniela Zeller, Department of Surgery, Zeller Surgery, Zurich 8008, Switzerland
Michael Scharl, Department of Gastroenterology, University Hospital of Zurich, Zurich 8091, Switzerland
Benjamin Misselwitz, Visceral Surgery and Medicine, University Hospital of Bern, Bern 3010, Switzerland
Author contributions: Misselwitz B, Rogler G, Turina M, Zeller D, Frei P, and Schneider C contributed to concept and design of the study; Misselwitz B, Rickenbacher A, Cabalzar-Wondberg D, Zeller D, and Biedermann L contributed to recruitment and clinical care of patients; Misselwitz B, Rickenbacher A, Cabalzar-Wondberg D, Zeller D, Biedermann L, Scharl M, Burk S, and Villiger R contributed to data acquisition; Villiger R and Misselwitz B contributed to statistical analysis; Misselwitz B, Villiger R, Rickenbacher A, and Cabalzar-Wondberg D contributed to interpretation of data; Villiger R, Misselwitz B, Cabalzar-Wondberg D, Rickenbacher A, Rogler G, and Zeller D contributed to drafting of the article and critical revisions to the manuscript; Cabalzar-Wondberg D and Villiger R contributed equally to this work and share the first authorship; Rickenbacher A and Misselwitz B contributed equally to this work and share the last authorship; all authors final approval of version of the article to be published.
Institutional review board statement: The study was reviewed and approved by the kantonalen Ethikkomission Zürich (Approval No. 2019-00208).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Benjamin Misselwitz, MD, Professor, Clinique for Visceral Surgery and Medicine, Inselspital Bern, University Hospital of Bern, Freiburgstrasse 4, Bern 3010, Switzerland.
Received: September 1, 2020
Peer-review started: September 1, 2020
First decision: October 23, 2020
Revised: November 20, 2020
Accepted: December 23, 2020
Article in press: December 23, 2020
Published online: February 27, 2021
Processing time: 156 Days and 8.4 Hours
Peer-review started: September 1, 2020
First decision: October 23, 2020
Revised: November 20, 2020
Accepted: December 23, 2020
Article in press: December 23, 2020
Published online: February 27, 2021
Processing time: 156 Days and 8.4 Hours
Core Tip
Core Tip: Perianal fistulae strongly impact on quality of life of affected patients. Despite various treatment options clinical care of fistula patients remains a challenge and novel minimally invasive treatment options are needed. Fistulodesis is feasible and safe for perianal fistula closure. Overall success rates is at 30% comparable to other similar techniques. A trend for better outcomes in patients with low perianal disease activity index needs to be confirmed.