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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Feb 27, 2021; 13(2): 164-175
Published online Feb 27, 2021. doi: 10.4240/wjgs.v13.i2.164
Published online Feb 27, 2021. doi: 10.4240/wjgs.v13.i2.164
Colorectal cancer of the young displays distinct features of aggressive tumor biology: A single-center cohort study
Matteo Mueller, Marcel André Schneider, Barla Deplazes, Daniela Cabalzar-Wondberg, Andreas Rickenbacher, Matthias Turina, Department of Surgery and Transplantation, University Hospital Zurich, Zurich 8091, Switzerland
Author contributions: Mueller M, Rickenbacher A and Turina M designed the research study; Mueller M, Schneider MA and Deplazes B performed the research; Mueller M, Schneider M, Cabalzar-Wondberg D, Rickenbacher A and Turina M analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript. Rickenbacher A and Turina M contributed equally as senior authors to this work.
Institutional review board statement: The study was approved by the local Ethics Committee of the Canton of Zurich (KEK-ZH-Nr. 2019-00208).
Conflict-of-interest statement: All the Authors have no conflict of interest related to the manuscript.
Data sharing statement: The original anonymous dataset is available on request from the corresponding author at matthias.turina@usz.ch.
STROBE statement: The authors have read the STROBE Statement checklist of items, and the manuscript was prepared and revised according to the STROBE Statement checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Matthias Turina, MD, PhD, Professor, Department of Surgery and Transplantation, University Hospital Zurich, Raemistrasse 100, Zurich 8091, Switzerland. matthias.turina@usz.ch
Received: November 24, 2020
Peer-review started: November 24, 2020
First decision: December 20, 2020
Revised: January 2, 2021
Accepted: January 21, 2021
Article in press: January 21, 2021
Published online: February 27, 2021
Processing time: 71 Days and 15.2 Hours
Peer-review started: November 24, 2020
First decision: December 20, 2020
Revised: January 2, 2021
Accepted: January 21, 2021
Article in press: January 21, 2021
Published online: February 27, 2021
Processing time: 71 Days and 15.2 Hours
Core Tip
Core Tip: We evaluated differences in tumor biology between young-onset colorectal cancer patients (< 50 years of age) and late-onset colorectal cancer (CRC) patients (≥ 50 years of age) in a Swiss tertiary cancer center over a six-year period. Parameters of interest included clinical as well as histopathological characteristics. This study reports a surprisingly high rate of CRC of young-onset, while affected patients present more frequently with locally advanced tumors, lymphatic invasion and with more frequent lymphatic metastases. This work puts cancer incidence in relation to histopathological details, mutational status, surgical parameters and selected risk factors.