Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2021; 13(12): 1651-1659
Published online Dec 27, 2021. doi: 10.4240/wjgs.v13.i12.1651
Effect of aluminum phosphate gel on prevention of early rebleeding after ligation of esophageal variceal hemorrhage
Zhu-Liang Zhang, Min-Si Peng, Ze-Ming Chen, Ting Long, Li-Sheng Wang, Zheng-Lei Xu
Zhu-Liang Zhang, Min-Si Peng, Ze-Ming Chen, Ting Long, Li-Sheng Wang, Zheng-Lei Xu, The Second Clinical Medical College of Jinan University, Shenzhen 518000, Guangdong Province, China
Zhu-Liang Zhang, Min-Si Peng, Ze-Ming Chen, Li-Sheng Wang, Zheng-Lei Xu, Department of Gastroenterology, Shenzhen People's Hospital, Shenzhen 518020, Guangdong Province, China
Ting Long, Department of Pathology, Shenzhen People’s Hospital, Shenzhen 518020, Guangdong Province, China
Author contributions: Xu ZL conceived the idea for the study; Zhang ZL, Peng MS, Chen ZM, Long T, and Xu ZL collected the case data and drafted the manuscript; Wang LS reviewed and revised the manuscript.
Supported by Natural Science Foundation of Guangdong Province of China, No. 2018A0303130278.
Institutional review board statement: The study was reviewed and approved by the ethics committee of Shenzhen People’s Hospital.
Informed consent statement: This study has received informed consent from all patients.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Data sharing statement: Dataset available from the corresponding author at 78249073@qq.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zheng-Lei Xu, MD, Associate Professor, Chief Doctor, The Second Clinical Medical College of Jinan University, No. 1017 Dongmen North Road, Shenzhen 518000, Guangdong Province, China. 78249073@qq.com
Received: April 27, 2021
Peer-review started: April 27, 2021
First decision: July 14, 2021
Revised: July 14, 2021
Accepted: November 14, 2021
Article in press: November 14, 2021
Published online: December 27, 2021
Core Tip

Core Tip: Esophageal variceal bleeding (EVB) is a common disease with a high mortality rate. Esophageal variceal ligation (EVL) is an effective means of hemostasis; however, ulcer foci of the esophagus can form after treatment. Patients with delayed healing of ulcers and unhealed ulcers are prone to experiencing early rebleeding. No studies have reported on the promotion of ulcer healing or prevention of rebleeding in EVB patients after EVL. This study showed that the application of aluminum phosphate gel in combination with a proton pump inhibitor after EVL significantly reduced the incidence of early rebleeding following endoscopic surgery in EVB patients.