Advances in liver transplantation for unresectable colon cancer liver metastasis

doi:10.4240/wjgs.v13.i12.1615

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Dec 27, 2021 (publication date) through Apr 26, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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World J Gastrointest Surg. Dec 27, 2021; 13(12): 1615-1627
Published online Dec 27, 2021. doi: 10.4240/wjgs.v13.i12.1615

Advances in liver transplantation for unresectable colon cancer liver metastasis

Xiao Cui, Xiao-Ping Geng, Da-Chen Zhou, Ming-Hao Yang, Hui Hou

Xiao Cui, Xiao-Ping Geng, Da-Chen Zhou, Ming-Hao Yang, Hui Hou, Department of General Surgery, The Second Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China

Author contributions: Cui X designed and wrote majority of the manuscript; Hou H designed and performed some parts of the manuscript; Geng XP made the revision; Zhou DC collected and analyzed the data; Yang MH collected and assembled the data.

Supported by Natural Science Foundation of the Higher Education Institutions of Anhui Province, No. KJ2017A825; and Natural Science Foundation of Anhui Province, No. 1808085MH270.

Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Hui Hou, MD, Professor, Department of General Surgery, The Second Hospital of Anhui Medical University, No. 678 Furong Road, Hefei 230601, Anhui Province, China. hui0402@hotmail.com

Received: July 3, 2021
Peer-review started: July 3, 2021
First decision: September 5, 2021
Revised: September 19, 2021
Accepted: December 6, 2021
Article in press: December 6, 2021
Published online: December 27, 2021

Core Tip

Core Tip: Liver transplantation (LT) for colorectal cancer liver metastasis (CRLM) has been explorally performed in the early stage of LT, but it was abandoned for its poorly oncological prognosis. Several newly released clinical studies showed the promising prospect of LT for CRLM. This review summarizes the history of LT for CRLM and lists the updated advancement in candidate selected criterion, potential immunosuppression and oncological safety balance strategies, surgical technique improvement and ongoing clinical trials.