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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Dec 27, 2021; 13(12): 1536-1549
Published online Dec 27, 2021. doi: 10.4240/wjgs.v13.i12.1536
Published online Dec 27, 2021. doi: 10.4240/wjgs.v13.i12.1536
Role of mesenteric component in Crohn’s disease: A friend or foe?
Yi Yin, Zhen-Xing Zhu, Zhun Li, Yu-Sheng Chen, Wei-Ming Zhu, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China
Author contributions: Yin Y and Zhu ZX contributed equally to this work; Yin Y and Zhu ZX designed and wrote the final version of the manuscript; Li Z and Chen YS were critical for the acquisition of data and drafting the manuscript; Zhu WM made critical revisions to the design and gave final approval for the article to be submitted.
Conflict-of-interest statement: All authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Ming Zhu, MD, PhD, Chief Doctor, Professor, Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. drweimingzhu@126.com
Received: January 29, 2021
Peer-review started: January 29, 2021
First decision: July 29, 2021
Revised: August 1, 2021
Accepted: November 25, 2021
Article in press: November 25, 2021
Published online: December 27, 2021
Peer-review started: January 29, 2021
First decision: July 29, 2021
Revised: August 1, 2021
Accepted: November 25, 2021
Article in press: November 25, 2021
Published online: December 27, 2021
Core Tip
Core Tip: Crohn’s disease (CD) is a complex autoimmune disease with increasing incidence worldwide, especially in Asian countries in recent years. There has been excellent progress in understanding the role of the mesentery in the pathogenesis and disease progress of CD. The crosstalk between components and intestinal inflammation has aroused many researchers’ interests. Herein, we will discuss the basic function and the alteration under inflammatory state of mesenteric nerves, blood vessels, lymphatics, and fat mass. Existing therapeutic strategies associated with mesentery components will also be summarized.