Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2021; 13(11): 1463-1483
Published online Nov 27, 2021. doi: 10.4240/wjgs.v13.i11.1463
Long-term survival of patients with stage II and III gastric cancer who underwent gastrectomy with inadequate nodal assessment
Jacopo Desiderio, Andrea Sagnotta, Irene Terrenato, Eleonora Garofoli, Claudia Mosillo, Stefano Trastulli, Federica Arteritano, Federico Tozzi, Vito D'Andrea, Yuman Fong, Yanghee Woo, Sergio Bracarda, Amilcare Parisi
Jacopo Desiderio, Stefano Trastulli, Federica Arteritano, Amilcare Parisi, Department of Digestive Surgery, St. Mary’s Hospital, Terni 05100, Italy
Jacopo Desiderio, Vito D'Andrea, Department of Surgical Sciences, Sapienza University of Rome, Rome 00161, Italy
Andrea Sagnotta, Department of General Surgery and Surgical Oncology, San Filippo Neri Hospital, Rome 00135, Italy
Irene Terrenato, Biostatistics and Bioinformatic Unit, Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome 00144, Italy
Eleonora Garofoli, Claudia Mosillo, Sergio Bracarda, Department of Medical Oncology, St. Mary’s Hospital, Terni 05100, Italy
Federico Tozzi, Division of Surgical Oncology and Endocrine Surgery, Mays Cancer Center, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, United States
Yuman Fong, Yanghee Woo, Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, LA, 91010, United States
Author contributions: Desiderio J, Sagnotta A and Terrenato I designed the study, conducted the research, collected the data, analyzed the results and drafted the manuscript; Terrenato I performed the statistics; Parisi A, D'Andrea V, Bracarda S, Woo Y and Fong Y supervised the study, and revised the manuscript; Trastulli S, Garofoli E, Mosillo C, Tozzi F confirmed the statistics, interpreted the data, and revised the manuscript; All authors read and approved the final manuscript.
Institutional review board statement: This is a study using a population-based registry, so institutional review board was not applicable.
Informed consent statement: This is a study using a population-based registry, so informed consent was not applicable.
Conflict-of-interest statement: The authors declare that they have no conflicting interests.
Data sharing statement: Further information is available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jacopo Desiderio, PhD, Academic Research, Surgeon, Surgical Oncologist, Department of Digestive Surgery, St. Mary’s Hospital, Via Tristano di Joannuccio 1, Terni 05100, Italy. j.desiderio@aospterni.it
Received: April 28, 2021
Peer-review started: April 28, 2021
First decision: June 17, 2021
Revised: June 30, 2021
Accepted: October 22, 2021
Article in press: October 22, 2021
Published online: November 27, 2021
Processing time: 211 Days and 22.8 Hours
Core Tip

Core Tip: A large database was analyzed to investigate survival outcomes related to lymph node assessment in locally advanced gastric cancer patients with radical gastrectomy. Independent of TNM-stage, the group with assessment of < 16 lymph nodes (LNs) had significantly worse survival than two other groups, 16-29 LNs and ≥ 30 LNs. Stage migration because of inadequate specimen analysis and improper lymphadenectomy was the main root cause.