Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Oct 27, 2021; 13(10): 1279-1284
Published online Oct 27, 2021. doi: 10.4240/wjgs.v13.i10.1279
Hodgkin lymphoma masquerading as perforated gallbladder adenocarcinoma: A case report
Michelle Manesh, Reynold Henry, Shea Gallagher, Michael Greas, Mohd Raashid Sheikh, Shannon Zielsdorf
Michelle Manesh, Reynold Henry, Shea Gallagher, Mohd Raashid Sheikh, Shannon Zielsdorf, Department of Surgery, University of Southern California, Los Angeles, CA 90033, United States
Michael Greas, Department of Pathology, University of Southern California, Los Angeles, CA 90033, United States
Author contributions: Manesh M, Henry R, Gallagher S and Zielsdorf S were the patient’s surgeons, reviewed the literature and contributed to manuscript drafting; Greas M performed the pathologic analyses and interpretation and contributed to manuscript drafting; Sheikh MR was responsible for the revision of the manuscript for important intellectual content; all authors issued final approval for the version to be submitted.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Reynold Henry, MD, Surgeon, Department of Surgery, University of Southern California, 2051 Marengo Street IPT, C5L100, Los Angeles, CA 90033, United States.
Received: April 20, 2021
Peer-review started: April 20, 2021
First decision: June 24, 2021
Revised: June 24, 2021
Accepted: August 30, 2021
Article in press: August 30, 2021
Published online: October 27, 2021
Core Tip

Core Tip: Here we present a case of Hodgkin lymphoma masquerading as gallbladder adenocarcinoma. In our patient, Hodgkin lymphadenopathy in the region of the porta hepatitis led to obstructions of the cystic and common hepatic ducts, causing acute cholecystitis and subsequent gallbladder perforation with associated cholangitis. Our case highlights the importance of histopathological assessment in diagnosing gallbladder malignancy when a patient presents with gallbladder perforation and a grossly positive positron emission tomography/computed tomography scan. For either gallbladder adenocarcinoma or Hodgkin lymphoma, chemotherapy tailored to the disease (and appropriate surgical intervention) are essential to achieve the best chance of cure and long-term survival.