Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2021; 13(1): 50-75
Published online Jan 27, 2021. doi: 10.4240/wjgs.v13.i1.50
Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer
Filippo Melli, Ilenia Bartolini, Matteo Risaliti, Rosaria Tucci, Maria Novella Ringressi, Paolo Muiesan, Antonio Taddei, Amedeo Amedei
Filippo Melli, Ilenia Bartolini, Matteo Risaliti, Rosaria Tucci, Maria Novella Ringressi, Paolo Muiesan, Antonio Taddei, Amedeo Amedei, Department of Clinical and Experimental Medicine, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Florence 50134, Italy
Author contributions: Melli F, Bartolini I, Risaliti M, and Tucci R contributed to original draft preparation; all the authors contributed to conceptualization and design of the study, data analysis and interpretation, critical revision of the article, and final approval of the version of the paper; Taddei A and Amedei A contributed to supervision.
Institutional review board statement: This study is under revision and approval by the Ethics Committee named Comitato Etico Area Vasta Centro.
Conflict-of-interest statement: All the authors have no financial relationships or any other conflicting interests to disclose.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at aamedei@unifi.it.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Amedeo Amedei, BSc, Reader (Associate Professor), Department of Clinical and Experimental Medicine, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla, 03, Firenze 50134, Italy. aamedei@unifi.it
Received: October 27, 2020
Peer-review started: October 27, 2020
First decision: November 30, 2020
Revised: December 9, 2020
Accepted: December 17, 2020
Article in press: December 17, 2020
Published online: January 27, 2021
Core Tip

Core Tip: In this retrospective study, several potential prognostic factors for recurrence, timing, and recurrence sites have been evaluated in patients who received curative colorectal surgery for adenocarcinoma with a potential minimum follow-up of 10 years. The independent prognostic factors for recurrence were the hospital stay, N stage 2, and M stage 1. Of note, younger ages were significantly associated with an early onset of recurrence. Some prognostic factors have been found for each site of recurrence: Liver, local, lung, and peritoneum. Thirty patients developed a second malignancy during the follow-up period. These findings may help in providing a tailored follow-up program.