Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointestinal Surgery. Apr 27, 2019; 11(4): 229-236
Published online Apr 27, 2019. doi: 10.4240/wjgs.v11.i4.229
Published online Apr 27, 2019. doi: 10.4240/wjgs.v11.i4.229
Malignant transformation of hepatocellular adenoma in a young female patient after ovulation induction fertility treatment: A case report
Juan Glinka, Rodrigo Sanchez Clariá, Eugenia Fratanoni, Victoria Ardiles, Oscar Mazza, Juan Pekolj, Martín de Santibañes, Eduardo de Santibañes, Department of General Surgery, Hepato-bilio-pancreatic Unit, Hospital Italiano de Buenos Aires, Buenos Aires C1181ACH, Argentina
Juan Spina, Department of Radiology, Hospital Italiano de Buenos Aires, Buenos Aires C1181ACH, Argentina
Eduardo Mullen, Department of Surgical Pathology, Hospital Italiano de Buenos Aires, Buenos Aires C1181ACH, Argentina
Author contributions: Glinka J and Fratantoni E designed the report; Fratantoni E collected the patient’s clinical data; Spina J and Mullen E provided relevant figures; Glinka J, Clariá RS, Ardiles V, Pekolj J, Mazza O, de Santibañes M and de Santibañes E analysed the data and wrote the paper.
Informed consent statement: Consent was obtained from the patient for publication.
Conflict-of-interest statement: The authors declare that no conflict of interest exists.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Juan Glinka, MD, Attending Doctor, Surgeon, HPB and Liver Transplantation Surgeon, Department of General Surgery, Hepato-bilio-pancreatic Unit, Hospital Italiano de Buenos Aires, Juan D. Perón 4190, Buenos Aires C1181ACH, Argentina. juan.glinka@hospitalitaliano.org.ar
Telephone: +54-11-49814501
Received: February 25, 2019
Peer-review started: February 25, 2019
First decision: March 11, 2019
Revised: March 26, 2019
Accepted: April 23, 2019
Article in press: April 23, 2019
Published online: April 27, 2019
Processing time: 61 Days and 12.1 Hours
Peer-review started: February 25, 2019
First decision: March 11, 2019
Revised: March 26, 2019
Accepted: April 23, 2019
Article in press: April 23, 2019
Published online: April 27, 2019
Processing time: 61 Days and 12.1 Hours
Core Tip
Core tip: As far as we know, this is the first report of a case involving a young woman with a small hepatocellular adenoma (HCA) with a stable behavior in a 6-year follow-up, who developed imaging changes suggesting malignancy after performing ovulation induction treatment. The patient underwent surgery due to diagnostic uncertainty, and the pathology report confirmed its malignancy. Therefore, we conclude that HCAs can be malignant regardless its size and low-risk appearance on magnetic resonance imaging when a hormone therapy is indicated.