Basic Study
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Feb 27, 2019; 11(2): 85-92
Published online Feb 27, 2019. doi: 10.4240/wjgs.v11.i2.85
In vivo expression of thrombospondin-1 suppresses the formation of peritoneal adhesion in rats
Yun-Sheng Tai, I-Ming Jou, Yun-Chih Jung, Chao-Liang Wu, Ai-Li Shiau, Chih-Yi Chen
Yun-Sheng Tai, Chih-Yi Chen, Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Yun-Sheng Tai, Department of Surgery, EDa Hospital, Kaohsiung 824, Taiwan
Yun-Sheng Tai, I-Shou University College of Medicine, Kaohsiung 824, Taiwan
I-Ming Jou, Department of Orthopedics, EDa Hospital, Kaohsiung 824, Taiwan
Yun-Chih Jung, Department of Pathology, Sinlau Christian Hospital, Tainan 701, Taiwan
Chao-Liang Wu, Department of Biochemistry, National Cheng Kung University Medical College, Tainan 701, Taiwan
Ai-Li Shiau, Department of Microbiology and Immunology, National Cheng Kung University Medical College, Tainan 701, Taiwan
Author contributions: Tai YS designed and performed the experiments; Jou IM, Wu CL and Shiau AL analyzed the data; Tai YS and Chen CY wrote the paper.
Institutional review board statement: Not applicable to this study.
Institutional animal care and use committee statement: This study protocol was reviewed and approved by the Affidavit of Approval of Animal Use Protocol National Cheng Kung University.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Chih-Yi Chen, MD, PhD, Doctor, Professor, Institute of Medicine, Department of Surgery, Chung Shan Medical University Hospital, No.110, Sec.1, Jianguo N. Rd, Taichung 402, Taiwan. cshy1566@csh.org.tw
Telephone: +886-4-24730022 Fax: +886-4-24723229
Received: November 2, 2018
Peer-review started: November 2, 2018
First decision: January 5, 2019
Revised: February 23, 2019
Accepted: February 24, 2019
Article in press: February 25, 2019
Published online: February 27, 2019
Core Tip

Core tip: Formation of intraperitoneal adhesions is one of the major complications after abdominal surgery, which may lead to bowel obstruction. Thrombospondin-1 (TSP-1) is an extracellular matrix modulating glycoprotein during tissue regeneration and collagen deposition. This study evaluated the therapeutic potential of overexpressed TSP-1 in suppressing pelvic adhesion formations in rat models. We found the application of Sperafilm reduced the formation of adhesion band, and local administration of adenoviral vectors encoding TSP-1 on the injured cecum the also attenuated the severity of peritoneal adhesion score. Therefore, therapeutic approaches in inducing regional overexpression of TSP-1 may serve as alternative treatment strategies for preventing postoperative peritoneal adhesion.