Xu WS, Zhang HY, Jin S, Zhang Q, Liu HD, Wang MT, Zhang B. Efficacy and safety of endoscopic submucosal dissection for early gastric cancer and precancerous lesions in elderly patients. World J Gastrointest Surg 2024; 16(2): 511-517 [PMID: PMC10921217 DOI: 10.4240/wjgs.v16.i2.511]
Corresponding Author of This Article
Hui-Yu Zhang, MSc, Doctor, Department of Gastroenterology, The Third Affiliated Hospital of Qiqihar Medical University, No. 27 Taishun Street, Tiefeng District, Qiqihar 161099, Heilongjiang Province, China. 32397208@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Wen-Si Xu, Hui-Yu Zhang, Shuang Jin, Qi Zhang, Hong-Dan Liu, Ming-Tao Wang, Bo Zhang, Department of Gastroenterology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161099, Heilongjiang Province, China
Author contributions: Xu WS and Zhang HY designed the study; Jin S, Zhang Q, Liu HD, Wang MT and Zhang B contributed to the data collection and analysis; Xu WS drafted the manuscript; All authors have read and approved the final manuscript.
Supported byQiqihar Scientific and Technological Plan Joint Guidance Projects, No. LSFGG-2023015.
Institutional review board statement: The study was reviewed and approved by The Third Affiliated Hospital of Qiqihar Medical University Institutional Review Board.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors report having no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui-Yu Zhang, MSc, Doctor, Department of Gastroenterology, The Third Affiliated Hospital of Qiqihar Medical University, No. 27 Taishun Street, Tiefeng District, Qiqihar 161099, Heilongjiang Province, China. 32397208@qq.com
Received: December 5, 2023 Peer-review started: December 5, 2023 First decision: December 21, 2023 Revised: January 5, 2024 Accepted: January 17, 2024 Article in press: January 17, 2024 Published online: February 27, 2024 Processing time: 82 Days and 8.4 Hours
ARTICLE HIGHLIGHTS
Research background
Endoscopic submucosal dissection (ESD) can realize curative en bloc resection of gastrointestinal superficial lesions as well as organ preservation in spite of some surgical risks such as perforation, intraoperative bleeding and prolonged operative duration.
Research motivation
Age is an important risk factor for the development of gastric cancer and meanwhile it influences the treatment options for gastric cancer, especially for the older patients who are more vulnerable to laparotomy.
Research objectives
This study aimed to investigate the efficacy and safety of ESD for the treatment of elderly patients with early gastric cancer and precancerous lesions.
Research methods
Surgical indexes, postoperative complications, recovery and prognosis were compared between patients with early gastric cancer and precancerous lesions undergoing ESD with those undergoing endoscopic mucosal resection (EMR).
Research results
ESD shows greater benefits in the aspects of the primary intraoperative conditions, postoperative short- and long-term recovery and functional status of gastric mucosa over EMR.
Research conclusions
ESD is a more effective option than EMR in the treatment of early gastric cancer and precancerous lesions in the elderly.
Research perspectives
Curative criteria after ESD for early gastric carcinoma should be considered in further studies to maximize the benefits of ESD for the recipients and provide evidence for the subsequent follow-up and treatment decision-making.
