Garzali IU, Akbulut S, Aloun A, Naffa M, Aksoy F. Outcome of split liver transplantation vs living donor liver transplantation: A systematic review and meta-analysis. World J Gastrointest Surg 2023; 15(7): 1522-1531 [PMID: 37555109 DOI: 10.4240/wjgs.v15.i7.1522]
Corresponding Author of This Article
Sami Akbulut, FACS, FICS, MD, PhD, Professor, Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Elazig Yolu 10. Km, Malatya 44280, Turkey. akbulutsami@gmail.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Meta-Analysis
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jul 27, 2023; 15(7): 1522-1531 Published online Jul 27, 2023. doi: 10.4240/wjgs.v15.i7.1522
Outcome of split liver transplantation vs living donor liver transplantation: A systematic review and meta-analysis
Ibrahim Umar Garzali, Sami Akbulut, Ali Aloun, Motaz Naffa, Fuat Aksoy
Ibrahim Umar Garzali, Department of Surgery, Aminu Kano Teaching Hospital, Kano 700101, Nigeria
Sami Akbulut, Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey
Sami Akbulut, Department of Biostatistics and Medical Informatics, Inonu University Faculty of Medicine, Malatya 44280, Turkey
Ali Aloun, Motaz Naffa, Royal Medical Services, King Hussein Medical Center, Amman 11855, Jordan
Fuat Aksoy, Department of Surgery, Uludag University Faculty of Medicine, Bursa 16059, Turkey
Author contributions: Garzali IU, Akbulut S, Aksoy F and Aloun A contributed to the conceptualization; Garzali IU and Aloun A contributed to the formal analysis; Garzali IU and Naffa M performed the methodology and wrote the original draft; Akbulut S and Garzali IU wrote the review and contributed to editing.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sami Akbulut, FACS, FICS, MD, PhD, Professor, Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Elazig Yolu 10. Km, Malatya 44280, Turkey. akbulutsami@gmail.com
Received: November 25, 2022 Peer-review started: November 25, 2022 First decision: February 20, 2023 Revised: February 22, 2023 Accepted: March 27, 2023 Article in press: March 27, 2023 Published online: July 27, 2023
ARTICLE HIGHLIGHTS
Research background
The outcome of liver transplantation (LT) may be affected by the type of graft implanted in the recipient. The graft may be from a deceased donor or from a living donor. Deceased donor graft may be whole graft or split graft.
Research motivation
To encourage the utilization of deceased donor split LT (DD-SLT) to increase the donor pool in LT.
Research objectives
To perform a systematic review and meta-analysis to compare the outcome of DD-SLT and living donor LT (LDLT).
Research method
This systematic review was performed in compliance with the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. A search was performed in research databases for articles comparing outcomes of DD-SLT and LDLT. Data were extracted from these studies for meta-analysis.
Research results
Patients that received LDLT had a better overall survival and graft survival.
Research conclusions
This meta-analysis showed that LDLT has a better graft survival and overall survival when compared to DD-SLT.
Research perspectives
To put the study in perspective, the type of graft affected the outcome of LT. Living donor graft has a superior outcome to deceased donor split graft.
